Adiponectin and Circulating Macrophage Phenotypes in Non-alcoholic Fatty Liver Disease (NAFLD)
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|ClinicalTrials.gov Identifier: NCT01472120|
Recruitment Status : Unknown
Verified August 2011 by Halil Genc, Gulhane School of Medicine.
Recruitment status was: Not yet recruiting
First Posted : November 16, 2011
Last Update Posted : November 16, 2011
|Condition or disease|
|Non-alcoholic Fatty Liver Disease|
In peripheral blood; monocytes and macrophages are found in two phenotype; proinflammatory M1 and anti-inflammatory M2 phenotypes.
M2 form is converted (or polarized) to M1 phenotype in various metabolic disorders such as obesity and type 2 diabetes mellitus. In addition, these forms also are related to insulin resistance and inflammation in adipose tissue.
Today, there is no study that investigate the role of adiponectin an anti-inflammatory adipokine, on macrophage polarization in non-alcoholic fatty liver disease.
|Study Type :||Observational|
|Estimated Enrollment :||160 participants|
|Observational Model:||Case Control|
|Official Title:||The Relationship of Adiponectin With Circulating Macrophage Phenotypes in Non-alcoholic Fatty Liver Disease|
|Study Start Date :||December 2011|
|Estimated Primary Completion Date :||September 2012|
|Estimated Study Completion Date :||January 2013|
P and C
P: NAFLD patients
C: Healthy controls
- For laboratory analyses, the collection of all blood samples from the study participants. [ Time Frame: Collection of blood samples in one year and analyses of data in 3 months. ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01472120
|Gastroenterology Department, Gulhane School of Medicine|
|Ankara,, Turkey, 06018|
|Principal Investigator:||halil genc, MD||Gulhane Medical School|