Heart Rate Variability of Patients With Bipolar Disorder in Subsyndromal Depressive Phase
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|ClinicalTrials.gov Identifier: NCT01455038|
Recruitment Status : Completed
First Posted : October 19, 2011
Last Update Posted : October 19, 2011
|Condition or disease|
|Bipolar Disorder Subsyndromal Depressive Phase Heart Rate Variability|
|Study Type :||Observational|
|Actual Enrollment :||92 participants|
|Observational Model:||Case Control|
|Official Title:||Heart Rate Variability of Patients With Bipolar Disorder in Subsyndromal Depressive Phase|
|Study Start Date :||January 2010|
|Actual Primary Completion Date :||April 2010|
|Actual Study Completion Date :||April 2010|
Healthy controls had no history of psychiatric disorder and had no psychiatric symptom when interviewed by a board-certified psychiatrist.
individual patient as being in subsyndromal depressive phase when the patient had a Montgomery-Åsberg depression rating scale score of 10 or less and Clinical Global Impression severity of 3 or less for last one month.
- Heart rate variability (HRV) [ Time Frame: at baseline ]
Time domain - NN (normal-to-normal R-R interval), HRV index (total number of all NN/ the height of the histogram of all NN), SDNN (standard deviation of the NN), RMSSD (the root mean square of differences of successive NN), NN50 (Number of pairs of adjacent NN intervals differing by more than 50 ms in the entire recording) and pNN50(NN50/total number of all NN).
Frequency domain - TP (The variance of NN intervals over the temporal segment), VLF(Power in very low frequency range; <0.04 Hz), LF(Power in low frequency range; 0.04~0.15 Hz), HF(Power in high frequency range; 0.15~0.4 Hz)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01455038
|Korea, Republic of|
|Asan medical center|
|Seoul, Korea, Republic of, 138-736|