Exertional Heat Illness: Biomarkers for Prediction and Return to Duty (Heat3)
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|ClinicalTrials.gov Identifier: NCT01434979|
Recruitment Status : Unknown
Verified January 2015 by Henry M. Jackson Foundation for the Advancement of Military Medicine.
Recruitment status was: Recruiting
First Posted : September 15, 2011
Last Update Posted : January 7, 2015
|Condition or disease|
|Exertional Heat Illness Exertional Heat Stroke Heat Intolerance|
|Study Type :||Observational|
|Estimated Enrollment :||150 participants|
|Observational Model:||Case Control|
|Study Start Date :||July 2011|
|Estimated Primary Completion Date :||January 2015|
|Cases who have suffered from Exertional Heat Illness / Stroke|
- Heat tolerance [ Time Frame: 2-hour heat test ]Heat tolerance is determined by physiologic response to a 2-hour heat tolerance test. During this test, participants with core temperature greater than 38.5 C and/or heart rate greater than 150 bpm are considered heat intolerant.
- Genetic response to heat tolerance [ Time Frame: 2-hour heat heat tolerance test ]DNA microarray will be conducted to see whether certain genes can predict response to the heat. Likewise, RNA microarray of RNA expression pre- and post-heat test will be conducted to further determine genetic pathways of heat intolerance.
- Fitness [ Time Frame: 2-hour heat tolerance test ]Body fat and aerobic capacity will be measured to quantify their contribution to heat tolerance.
- Behavioral correlates of heat tolerance [ Time Frame: past month ]Questionnaires will be used to assess behavioral correlates of heat tolerance, including measures of sleep impairment and executive dysfunction.
- Perceived heat strain [ Time Frame: 2-hour heat tolerance test and 2-hour control test ]Measures of perceived heat strain will be recorded to determine how accurately participants perceive that they are working in the heat, and whether this adds diagnostic value to the heat test.
- Blood pressure in response to heat tolerance [ Time Frame: 2-hour heat tolerance test and 2-hour control test ]Blood pressure will be recorded to see whether it blood pressure response to exercise in the heat correlates with heat tolerance.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01434979
|Contact: Josh B Kazman, MSfirstname.lastname@example.org|
|United States, Maryland|
|Uniformed Services University of the Health Sciences||Recruiting|
|Bethesda, Maryland, United States, 20814|
|Contact: Josh B Kazman, MS 301-295-9251 email@example.com|
|Principal Investigator: Patricia Deuster, PhD, MPH|
|Heller Institute of Medical Research||Not yet recruiting|
|Contact: Yuval Heled, PhD, FACSM 035303564 Yuval.Heled@sheba.health.gov.il|
|Contact: Chen Fleischmann, MS (+972) - (0)3-5303565/4 Chen.Fleischmann@sheba.health.gov.il|
|Principal Investigator: Yuval Heled, PhD, FACSM|
|Principal Investigator:||Patricia Deuster, PhD, MPH||Uniformed Services University of the Health Sciences|