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Progesterone on the Day of Ovulation Induction is Associated With Pregnancy Outcome (ProgBBN)

This study has been completed.
Information provided by (Responsible Party):
Bollmann Bruckner Noss Identifier:
First received: August 28, 2011
Last updated: August 29, 2011
Last verified: August 2011
Progesterone levels measured in blood/serum of patients on the day of ovulation induction following controlled ovarian stimulation for in vitro fertilization may be associated with pregnancy outcome. The hypothesis is that higher progesterone levels are associated with lower implantation rates due to changes in the endometrial receptivity.

Female Infertility

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Association Between Progesterone Levels on the Day of Ovulation Induction and IVF Outcome: Retrospective Study With 2500 Controlled Ovarian Stimulations Cycles

Resource links provided by NLM:

Further study details as provided by Bollmann Bruckner Noss:

Primary Outcome Measures:
  • Ongoing pregnancy rate [ Time Frame: 13 weeks ]
    Patients will be followed up from embryotransfer until second trimester of pregnancy

Secondary Outcome Measures:
  • Delivery after 23.gestational weeks [ Time Frame: 9 months ]
    Patients will be followed up from embryotransfer until delivery

Enrollment: 2555
Study Start Date: January 2006
Study Completion Date: April 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
Low level progesterone group (1)
Progesterone < 1.50 ng/mL on day of ovulation induction
Medium level progesterone group (2)
Progesterone 1.51-1.99 ng/mL on the day of ovulation induction
High level progesterone group (3)
Progesterone > 1.99 ng/mL on the day of ovulation induction


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Female patients with infertility undergoing assisted reproduction techniques, i.e. in vitro fertilization.

Inclusion Criteria:

  • IVF/ICSI following controlled ovarian stimulation
  • progesterone measured on the day of ovulation induction
  • informed consent

Exclusion Criteria:

  • missing consent
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Please refer to this study by its identifier: NCT01426152

Praxis Bollmann-Brückner-Noss
Munich, Bavaria, Germany, 80331
Sponsors and Collaborators
Bollmann Bruckner Noss
Principal Investigator: Robert Ochsenkuehn, MD Center for Reproductive Medicine
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Bollmann Bruckner Noss Identifier: NCT01426152     History of Changes
Other Study ID Numbers: Prog2006-2011
BBN ( Other Identifier: Center for Reproductive Medicine )
Study First Received: August 28, 2011
Last Updated: August 29, 2011

Keywords provided by Bollmann Bruckner Noss:
ovulation induction
pregnancy rates
Female Infertility Due to Nonimplantation

Additional relevant MeSH terms:
Infertility, Female
Genital Diseases, Male
Genital Diseases, Female
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs processed this record on May 25, 2017