Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction (R²ACE)

This study has been completed.
Information provided by (Responsible Party):
M Claeys, Universiteit Antwerpen Identifier:
First received: August 10, 2011
Last updated: July 19, 2015
Last verified: July 2015
There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on remodeling, mainly through stimulation of neo-revascularisation. Clinical data on these issues are lacking. This clinical project studies the role of adiponectin, endothelial progenitor cells and endothelial microparticles in the ischaemia-reperfusion process and the compensatory ventricular remodelling in a population of 250 infarction patients treated with primary PCI. If the role of these factors could be confirmed in this clinical setting, those factors might represent a new target for therapeutic interventions in AMI patients.

Myocardial Infarction
Reperfusion Injury

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Reperfusion Injury and Cardiac Remodelling After Myocardial Infarction in Relation to Adiponectin Level, Circulating Endothelial Progenitor Cells and Endothelial Microparticles

Resource links provided by NLM:

Further study details as provided by Universiteit Antwerpen:

Primary Outcome Measures:
  • occurrence of reperfusion injury after succesfull primary PCI [ Time Frame: within 90 min after PCI ] [ Designated as safety issue: No ]
    Serial ECG measurements (before and after PCI to assess extent of ST segment resolution as marker of reperfusion injury

Secondary Outcome Measures:
  • Major cardiovascular event rate [ Time Frame: at 1 year ] [ Designated as safety issue: Yes ]
    combined endpoint of hospitalisation (or extension of hospitalisation) for heart failure and cardiac death in a period of one year

Biospecimen Retention:   Samples Without DNA
blood samples

Enrollment: 250
Study Start Date: April 2011
Study Completion Date: December 2013
Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
STEMI patients
Patients with ST elevation myocardial infarction,lasting <12 hour, who were succesfully treated with primary PCI


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
ST elevetion myocardial infarction patients

Inclusion Criteria:

  • STEMI treated with primary PCI

Exclusion Criteria:

  • ischemia time >12h
  • use of immunosuppressive therapy
  • unsuccessful recanalisation
  • not-interpretable ST-T segment
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01414452

University hospital
Edegem, Antwerp, Belgium, 2650
Sponsors and Collaborators
Universiteit Antwerpen
Principal Investigator: Marc Claeys, MD PHD University Hospital, Antwerp
  More Information

Responsible Party: M Claeys, Prof dr, Universiteit Antwerpen Identifier: NCT01414452     History of Changes
Other Study ID Numbers: UAntwerpen 
Study First Received: August 10, 2011
Last Updated: July 19, 2015
Health Authority: Belgium: Institutional Review Board

Keywords provided by Universiteit Antwerpen:
Myocardial Infarction
Reperfusion injury
endothelial progenitor cells

Additional relevant MeSH terms:
Myocardial Infarction
Reperfusion Injury
Cardiovascular Diseases
Heart Diseases
Myocardial Ischemia
Pathologic Processes
Postoperative Complications
Vascular Diseases processed this record on May 22, 2016