Centralized Off-Site Adherence Enhancement Program (CARE)
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ClinicalTrials.gov Identifier: NCT01409655 |
Recruitment Status
:
Completed
First Posted
: August 4, 2011
Last Update Posted
: February 25, 2016
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
HIV/AIDS, Medication Adherence | Behavioral: cognitive-behavioral therapy | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 42 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Centralized Off-Site Adherence Enhancement Program |
Study Start Date : | August 2011 |
Actual Primary Completion Date : | November 2014 |
Actual Study Completion Date : | November 2014 |

Arm | Intervention/treatment |
---|---|
Experimental: cognitive-behavioral therapy intervention
Reinforcement for medication-taking will be wired to debit cards that patients will be given to receive the payments. This contingent reinforcement of medication-taking will be coupled with twelve sessions of cognitive-behavioral therapy (CBT) conducted by phone, also assisted by the website which will generate CBT-related text messages, reminders and scheduling information from a menu of choices negotiated by the patient and therapist.
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Behavioral: cognitive-behavioral therapy
. Reinforcement for medication-taking will be wired to debit cards that patients will be given to receive the payments. This contingent reinforcement of medication-taking will be coupled with twelve sessions of cognitive-behavioral therapy (CBT) conducted by phone, also assisted by the website which will generate CBT-related text messages, reminders and scheduling information from a menu of choices negotiated by the patient and therapist.
Other Name: CARE
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- change of adherence to antiretroviral medications measured at weeks 0, 4, 8, 12, 16, 20, and 24 [ Time Frame: weeks 0, 4, 8, 12, 16, 20, and 24. ]collect information about adherence and behaviroal measures

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Current treatment with antiretroviral medications
- Within the last sixty days, either (a) Self-reported risky alcohol use (defined as >14 drinks/week or >4 drinks/occasion for men 65 or younger; >7 drinks/week or >3 drinks/occasion for women); OR (b) >=two days of either cocaine or amphetamine use
- Able to provide voluntary informed consent as evidenced by ability to answer questions about the consent form
- Able and willing to use SimPill caps to store at least one antiretroviral medication
Exclusion Criteria:
- Physiological dependence on alcohol, illicit opioids or sedatives as assessed by the history and symptom review procedures
- Dispensed medications in a monitored setting
- Unable to speak English. The need for bilingual staff and cross-coverage to enroll monolingual Hispanic people is beyond this study's scope.
- Will not be able to complete the study because of anticipated incarceration or move

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01409655
United States, California | |
University of California, Los Angeles | |
Los Angeles, California, United States, 90095 |
Responsible Party: | Honghu Liu, Principal Investigator, University of California, Los Angeles |
ClinicalTrials.gov Identifier: | NCT01409655 History of Changes |
Other Study ID Numbers: |
R34DA031643 ( U.S. NIH Grant/Contract ) |
First Posted: | August 4, 2011 Key Record Dates |
Last Update Posted: | February 25, 2016 |
Last Verified: | February 2016 |
Keywords provided by Honghu Liu, University of California, Los Angeles:
AIDS, HIV, Adherence, Compliance, Contingency management |