Nutritional Status and Prognosis in Heart Failure. (PLICA)
The purpose of this study is to determine whether nutritional status or body composition influences the prognosis of heart failure patients.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Nutrition Status and Body Composition in Ambulatory Patients With Heart Failure and Its Prognostic Significance (PLiegues en Insuficiencia Cardiaca-PLICA).|
- All cause mortality [ Time Frame: 3 years ] [ Designated as safety issue: No ]
- Cardiac mortality and non-cardiac mortality [ Time Frame: 3 years ] [ Designated as safety issue: No ]
- Heart failure hospitalizations [ Time Frame: 3 years ] [ Designated as safety issue: No ]
|Study Start Date:||June 2011|
|Study Completion Date:||September 2014|
|Primary Completion Date:||July 2013 (Final data collection date for primary outcome measure)|
Heart failure patients attending a HF clinic with depressed LVEF (< 45%) or ≥ 1 hospital admission due to HF decompensation.
Other: No intervention
Despite obesity is a cardiovascular risk factor, numerous studies have identified a better prognosis in overweight and obese heart failure (HF) patients. This paradox has been named "the obesity paradox". However, this paradox has been criticized because the parameter used to classify obesity, the body mass index (BMI), has several limitations. Obesity is defined as an abnormal or excessive fat accumulation, and BMI does not always reflect real body fat.
What is more, patients with HF can have their body composition altered with hyperhydration or undernourishment. A pilot study proved that BMI does not indicate true nutritional status in HF. Thus, a further assessment of body composition of HF patients, analyzing the nutritional status rather BMI, could shed light on the obesity paradox. The aim of this study was to assess the nutritional status of a cohort of HF patients, its correspondence with BMI, and its significance in terms of survival.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01396824
|Germans Trias Research Institute; Germans Trias University Hospital|
|Badalona, Barcelona, Spain, 08916|