Effects of Sildenafil in Resistant Hypertensives and Genetic Polymorphism
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|ClinicalTrials.gov Identifier: NCT01392638|
Recruitment Status : Completed
First Posted : July 12, 2011
Last Update Posted : October 30, 2012
|Condition or disease||Intervention/treatment||Phase|
|Hypertension||Other: sugar pill Drug: sildenafil||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||120 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Influence of the Nitric Oxide Synthase T-786C Polymorphism on the Response to Acute Inhibition of Phosphodiesterase 5 in Resistant Hypertension|
|Study Start Date :||July 2010|
|Actual Primary Completion Date :||July 2012|
|Actual Study Completion Date :||September 2012|
Placebo Comparator: sugar pill
Intervention: sugar pill
Other: sugar pill
Sugar pills: 37.5, 50.0, and 100.0 mg each 30 minutes.
Other Name: No brand name.
Active Comparator: sildenafil
Intervention: sildenafil citrate
Sildenafil pills: 37.5, 50.0, and 100.0 mg each 30 minutes.
Other Name: Viagra, Pfizzer Lab., USA
- Cardiac Output, total peripheral resistance, mean arterial pressure [ Time Frame: Each 30 minutes ]Hemodynamic measures each 30 minutes
- Left ventricular diastolic function parameters, endothelial function [ Time Frame: Pre- and post-sildenafil accumulated doses ]Assessment of how hemodynamic changes determined by sildenafil would affect endothelial and left ventricular diastolic parameters.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01392638
|Laboratory of Cardiovascular Pharmacology - FCM - Unicamp|
|Campinas, SP, Brazil|
|Principal Investigator:||Heitor Moreno, PhD||Faculty of Medical Sciences - Unicamp|