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Urine Adiponectin Concentration in Prediction of Contrast Induced Nephropathy

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2011 by Xijing Hospital.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Xijing Hospital Identifier:
First received: June 10, 2011
Last updated: November 21, 2011
Last verified: November 2011
The present study is to determine the ability of urinary total adiponectin and its isoforms excretion in the prediction of contrast induced nephropathy (CIN) in the patients undergoing PCI.

Myocardial Ischemia

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Urine Total Adiponectin and Its Isoforms Concentration in Prediction of Percutaneous Coronary Interventions Contrast Induced Nephropathy

Resource links provided by NLM:

Further study details as provided by Xijing Hospital:

Primary Outcome Measures:
  • increase in SCr 0.5 mg/dL(44.2 mol/L) from baseline [ Time Frame: 3 days ]
    samples will be collected at 24, 48 and 72 hours after PCI

Secondary Outcome Measures:
  • a 25% increase in SCr from baseline [ Time Frame: 3 days ]
    samples will be collected at 24, 48 and 72 hours after PCI.

Biospecimen Retention:   Samples Without DNA

Estimated Enrollment: 400
Study Start Date: April 2010
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: April 2013 (Final data collection date for primary outcome measure)
Patients underging PCI

Detailed Description:
Contrast induced nephropathy (CIN) is a severe complication after percutaneous coronary intervention (PCI). CIN is responsible for approximately genic renal insufficiency and is the third cause of hospital-acquired renal failure and the injury of endothelial of renal tubule is responsible for the CIN. However markers reliably identifying CIN in the patients undergoing PCI are rare. Adiponectin is a 30-kDa adipocyte-derived vasoactive peptide closely linked to components of the metabolic syndrome. Recent study demonstrates that the quantification of urinary adiponectin excretion appears to be an independent indicator of vascular damage potentially identifying an increased risk for vascular events. Therefore, the investigators presume that the adiponectin excretion may predict the incidence of the CIN. The present study is to determine the ability of urinary total adiponectin and its isoforms excretion in the prediction of CIN in the patients undergoing PCI.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
This study enrolls a group of patients> 18 who have ST elevation myocardial infarction (STEMI) undergoing primary PCI.

Inclusion Criteria:

  • All patients > 18 of age who are undergoing elective PCI and are able to give informed consent are eligible for study.

Exclusion Criteria:

  • The end-stage renal failure
  • The patients who are relieving dialysis
  Contacts and Locations
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Please refer to this study by its identifier: NCT01372891

Contact: Ling Tao, M.D Ph.D +86-15002955798

China, Shaanxi
Xijing Hospital Recruiting
Xi'an, Shaanxi, China, 710032
Contact: Ling Tao, M.D Ph.D    +86-15002955798   
Principal Investigator: Ling Tao, M.D Ph.D         
Sponsors and Collaborators
Xijing Hospital
  More Information

Responsible Party: Xijing Hospital Identifier: NCT01372891     History of Changes
Other Study ID Numbers: xjyy110502
Study First Received: June 10, 2011
Last Updated: November 21, 2011

Keywords provided by Xijing Hospital:
Contrast Induced Nephropathy
percutaneous coronary interventions

Additional relevant MeSH terms:
Kidney Diseases
Myocardial Ischemia
Coronary Artery Disease
Pathologic Processes
Urologic Diseases
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Coronary Disease
Arterial Occlusive Diseases processed this record on May 25, 2017