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Hyperbaric Oxygen Treatment Ameliorates Insulin Resistance (HOTAIR)

This study has been completed.
Information provided by (Responsible Party):
A/Prof Leonie Heilbronn, University of Adelaide Identifier:
First received: May 24, 2011
Last updated: September 17, 2013
Last verified: September 2013
Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have preliminary evidence showing that hyperbaric oxygen therapy rapidly increases insulin sensitivity in humans. This requires confirmation in a larger population, and with this study the investigators will also test for mechanisms how this occurs. The investigators suspect that modulation of hypoxia and stress response proteins following changes in tissue oxygenation may contribute to these improvements. This study has the potential to yield new and important insights into the insulin resistance in obesity.

Condition Intervention
Type 2 Diabetes
Procedure: Hyperbaric Oxygen Treatment

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Hyperbaric Oxygen Treatment Ameliorates Insulin Resistance

Resource links provided by NLM:

Further study details as provided by University of Adelaide:

Primary Outcome Measures:
  • Insulin sensitivity [ Time Frame: 1 year ]
    Using Hyperinsulinemic clamp

Secondary Outcome Measures:
  • Hypoxia and inflammatory markers [ Time Frame: 1 year ]
    using IHC, qPCR, Western blot

Enrollment: 20
Study Start Date: April 2011
Study Completion Date: January 2013
Primary Completion Date: January 2013 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: Hyperbaric Oxygen Treatment
    Participants will undergo 4 treatments of hyperbaric oxygen. Each treatment consists of 90 minutes compression at 2 atmospheres of pressure, with 30 minutes decompression back to 1 atmosphere, during this time, patients will be treated with 100% Oxygen delivered via a hood system.

Ages Eligible for Study:   45 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Obese men with and without type 2 diabetes aged 45-70
  • Lean men without type 2 diabetes aged 45-70

Exclusion Criteria:

  • smokers
  • claustrophobic
  • sleep apnoea
  • blood donor
  • exercise more than 2 times per week
  • under certain medications eg: bleomycin,corticosteroid
  Contacts and Locations
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Please refer to this study by its identifier: NCT01361971

Australia, South Australia
University of Adelaide
Adelaide, South Australia, Australia
Sponsors and Collaborators
University of Adelaide
Principal Investigator: Leonie K Heilbronn, Phd University of Adelaide
  More Information

Responsible Party: A/Prof Leonie Heilbronn, A/Prof, University of Adelaide Identifier: NCT01361971     History of Changes
Other Study ID Numbers: RAH100615
Study First Received: May 24, 2011
Last Updated: September 17, 2013

Keywords provided by University of Adelaide:
Insulin resistance

Additional relevant MeSH terms:
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on May 22, 2017