Comparison of Effect-site Concentration of Remifentanil for Preventing Cough Against Endotracheal Tube During Anesthetic Emergence According to Anesthetics (Sevoflurane, Desflurane, and Propofol)
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ClinicalTrials.gov Identifier: NCT01351285 |
Recruitment Status
:
Completed
First Posted
: May 10, 2011
Last Update Posted
: June 4, 2013
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Female Patients Undergoing Thyroidectomy | Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 78 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single (Outcomes Assessor) |
Study Start Date : | April 2011 |
Actual Primary Completion Date : | October 2011 |
Actual Study Completion Date : | October 2011 |

Arm | Intervention/treatment |
---|---|
Experimental: Sevo group
undergoing sevoflurane-remifentanil anesthesia
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Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough
During the emergence from anesthesia, if the patient did not cough, the extubation was defined as smooth emergence and the predetermined effect site concentration of remifentanil for the subsequent patient was decreased by 0.5 ng/mL. Likewise, if the patient coughed anytime around extubation, it was considered a failed smooth emergence and the predetermined effect site concentration for the next patient was increased by 0.5 ng/mL. This up-and-down method was conducted independently for each of the three groups. EC50 of the remifentanil of each group was obtained using the Dixon's method.
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Active Comparator: Des group
undergoing desflurane-remifentanil anesthesia
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Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough
During the emergence from anesthesia, if the patient did not cough, the extubation was defined as smooth emergence and the predetermined effect site concentration of remifentanil for the subsequent patient was decreased by 0.5 ng/mL. Likewise, if the patient coughed anytime around extubation, it was considered a failed smooth emergence and the predetermined effect site concentration for the next patient was increased by 0.5 ng/mL. This up-and-down method was conducted independently for each of the three groups. EC50 of the remifentanil of each group was obtained using the Dixon's method.
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Active Comparator: Pro group
undergoing propofol-remifentanil anesthesia
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Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough
During the emergence from anesthesia, if the patient did not cough, the extubation was defined as smooth emergence and the predetermined effect site concentration of remifentanil for the subsequent patient was decreased by 0.5 ng/mL. Likewise, if the patient coughed anytime around extubation, it was considered a failed smooth emergence and the predetermined effect site concentration for the next patient was increased by 0.5 ng/mL. This up-and-down method was conducted independently for each of the three groups. EC50 of the remifentanil of each group was obtained using the Dixon's method.
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- occurrence of cough [ Time Frame: From the completion of surgery to 5minute after extubation ]We will assess the occurrence of cough during emergence from general anesthesia in female patients undergoing target controlled infusion of remifentanil at predetemined concentration.

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Ages Eligible for Study: | 20 Years to 60 Years (Adult) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- aged 20-60
- ASA classification I~II
- female patients
- patients who undergoing thyroidectomy
Exclusion Criteria:
- Patients with acute or chronic respiratory disease
- patient who has smoking history
- patient who has hypertension
- patient who has esophageal reflux
- patient who having an expectorant or cough remedy

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01351285
Korea, Republic of | |
Severance Hospital | |
Seoul, Korea, Republic of, 120-752 |
Responsible Party: | Yonsei University |
ClinicalTrials.gov Identifier: | NCT01351285 History of Changes |
Other Study ID Numbers: |
4-2011-0019 |
First Posted: | May 10, 2011 Key Record Dates |
Last Update Posted: | June 4, 2013 |
Last Verified: | June 2013 |
Additional relevant MeSH terms:
Remifentanil Sevoflurane Desflurane Analgesics, Opioid Narcotics Central Nervous System Depressants Physiological Effects of Drugs Analgesics |
Sensory System Agents Peripheral Nervous System Agents Hypnotics and Sedatives Anesthetics, Intravenous Anesthetics, General Anesthetics Platelet Aggregation Inhibitors Anesthetics, Inhalation |