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Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways

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ClinicalTrials.gov Identifier: NCT01350427
Recruitment Status : Completed
First Posted : May 9, 2011
Last Update Posted : February 25, 2013
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.

Condition or disease Intervention/treatment
Healthy Dietary Supplement: Leucine supplementation Dietary Supplement: BCAA supplementation Dietary Supplement: Alanine supplementation

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 18 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Leucine, Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Remodelling Signaling Pathways: a Randomized, Double-blind, and Placebo-controlled Study
Study Start Date : August 2011
Primary Completion Date : February 2013
Study Completion Date : February 2013

Resource links provided by the National Library of Medicine

Drug Information available for: Leucine
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: Leucine Dietary Supplement: Leucine supplementation
1 bout of resistance exercise and supplementation of 4.0 g of leucine + 5.6 g of alanine
Experimental: BCAA Dietary Supplement: BCAA supplementation
1 bout of resistance exercise and supplementation of 4.0 g of leucine + 2.8 g of isoleucine + 2.8 g of valine
Placebo Comparator: Placebo Dietary Supplement: Alanine supplementation
1 bout of resistance exercise and supplementation of 9.6 g of alanine


Outcome Measures

Primary Outcome Measures :
  1. Protein synthesis [ Time Frame: 1 hour ]
    Phosphorylation of proteins involved in protein synthesis

  2. Protein degradation [ Time Frame: 1 hour ]
    Expression of protein involved in proteolytic pathway

  3. Inflammation [ Time Frame: 1 hour ]
    Expression of systemic and muscular cytokines


Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Sedentaries
  • Must be able to exercise
  • Must be able to swallow tablets

Exclusion Criteria:

  • Use of nutritional supplements
  • Use of anti-inflammatory drugs
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01350427


Locations
Brazil
University of São Paulo - School of Physical Education and Sports
São Paulo, Brazil, 05508-030
Sponsors and Collaborators
University of Sao Paulo
Investigators
Principal Investigator: Claudia R da Luz, Master Student University of São Paulo
More Information

Responsible Party: Humberto Nicastro, PhD, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT01350427     History of Changes
Other Study ID Numbers: 2011/04690-6
First Posted: May 9, 2011    Key Record Dates
Last Update Posted: February 25, 2013
Last Verified: February 2013

Keywords provided by Humberto Nicastro, University of Sao Paulo:
leucine supplementation
BCCA supplementation
resistance exercise-induced muscle remodeling