ACToR-study : Angiographic CT of Renal Transplantation Candidate - Study (ACToR)
|ClinicalTrials.gov Identifier: NCT01344434|
Recruitment Status : Completed
First Posted : April 29, 2011
Last Update Posted : April 10, 2014
|Condition or disease|
|Renal Transplant Candidate for Right Kidney Renal Transplant Candidate for Left Kidney|
Chronic kidney disease is a known risk factor for cardiovascular disease and cardiovascular disease is the leading cause of mortality in end-stage renal disease (ESRD) patients. After renal transplantation one-half of all deaths are cardiac, usually in the first 5 years in the presence of a functional graft. Because of this renal transplantation candidates are undergoing cardiac pre-transplant risk stratification.
There is no consensus regarding which modality should be use for detection of CAD in this cardiac pre-transplant risk stratification. CAG is known as gold standard but is a invasive procedure with risk of complication.
The investigators wish to investigate the ability of detecting CAD as defined by invasive Coronary angiography (CAG) by clinical examination, blood test and non-invasive test (cCTA, MPS and acoustic CAD Patch). The investigators hypothesize that a single modality or combination of these with high sensitivity and specificity could diagnose significant CAD without the need of further invasive procedures.
This study will include 150 renal transplantations candidate.
|Study Type :||Observational|
|Actual Enrollment :||167 participants|
|Official Title:||Angiographic CT of Renal Transplantation Candidate - Study|
|Study Start Date :||February 2011|
|Actual Primary Completion Date :||February 2014|
|Actual Study Completion Date :||February 2014|
- To investigate the ability of non-invasive tests to detect CAD as defined by invasive angiography in renal transplantation candidates. [ Time Frame: 2013 october ]Baseline results of coronary computed tomographic angiography (cCTA), myocardial perfusion scintigraphy (MPS), acoustic CAD Patch and combination hereof to detect CAD as defined by invasive Coronary angiography (CAG).
- To investigate the risk of Contrast-Induced Nephropathy (CIN) after cCTA and CAG. [ Time Frame: 2013 october ]Blood sample of creatinine after contrast exposure.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01344434
|Aarhus, Denmark, 8200|
|Principal Investigator:||Simon Winther, MD||Department of Cardiology, Skejby Sygehus, Denmark|