Try the modernized beta website. Learn more about the modernization effort.
Working… Menu

Endogenous Endophthalmitis in the Inpatient Setting

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01323868
Recruitment Status : Completed
First Posted : March 28, 2011
Last Update Posted : November 18, 2014
Information provided by (Responsible Party):
Theodore Leng, Stanford University

Brief Summary:
The purpose of this study is to determine the rate of endogenous endophthalmitis in patients admitted to Stanford Hospital with a systemic infection and positive blood cultures, as this may improve the clinical care of this population of patients.

Condition or disease

Detailed Description:

Some patients admitted to the hospital have blood-borne infections. Occasionally, these blood infections can end up inside the eye and cause an infection inside the eye (called endogenous endophthalmitis).

Prior to modern and rapid treatment of systemic infections, the rate of endogenous endophthalmitis was reported to be 37% in 1982. By 1997, the rate was reported to be 2.8%. This study aims to determine the rate of endogenous endophthalmitis at Stanford Hospital in the modern medical era in that our rates may be different as those reported in the literature. This potential difference may be a reflection of treatment protocols and antibiotics currently in use at Stanford Hospital.

Layout table for study information
Study Type : Observational
Actual Enrollment : 145 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Endogenous Endophthalmitis Rates, Clinical Course, and Outcomes
Study Start Date : July 2010
Actual Primary Completion Date : June 2013
Actual Study Completion Date : June 2013

Primary Outcome Measures :
  1. Positive intraocular infection [ Time Frame: 1 day ]

Secondary Outcome Measures :
  1. Visual acuity [ Time Frame: 2 wk ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Inpatients at Stanford Hospital with positive blood cultures who receive an Ophthalmology consultation and eye examination.
Inclusion Criteria:All patients admitted to Stanford Hospital that have a systemic blood-borne infection and on which an Ophthalmology consult to rule out endogenous endophthalmitis is performed will be included in the study. Exclusion Criteria:None

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01323868

Layout table for location information
United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Layout table for investigator information
Principal Investigator: Theodore Leng Stanford University
Layout table for additonal information
Responsible Party: Theodore Leng, Clinical Assistant Professor of Ophthalmology, Stanford University Identifier: NCT01323868    
Other Study ID Numbers: SU-03232011-7621
First Posted: March 28, 2011    Key Record Dates
Last Update Posted: November 18, 2014
Last Verified: November 2014
Additional relevant MeSH terms:
Layout table for MeSH terms
Eye Infections
Eye Diseases