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Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery (TRIMRIPC)

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ClinicalTrials.gov Identifier: NCT01308138
Recruitment Status : Completed
First Posted : March 3, 2011
Last Update Posted : August 20, 2015
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

Condition or disease Intervention/treatment
Myocardial Injury Behavioral: Exercise training Procedure: remote ischemic preconditioning

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function
Study Start Date : January 2011
Primary Completion Date : May 2013
Study Completion Date : July 2013
Arms and Interventions

Arm Intervention/treatment
Experimental: ExerciseTr Behavioral: Exercise training
exercise training
Experimental: Remote ischemic preconditioning group Procedure: remote ischemic preconditioning
remote ischemic preconditioning
No Intervention: Control patient group


Outcome Measures

Primary Outcome Measures :
  1. Mitochondrial respiration [ Time Frame: 1 hour ]
    Oxygraph (Strathkelvin)


Eligibility Criteria

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients undergoing coronary heart surgery and heart transplantation

Exclusion Criteria:

  • myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01308138


Locations
Norway
Norwegian University of Science and Technology, Medical Faculty
Trondheim, Sør-Trondelag, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
St. Olavs Hospital
Investigators
Principal Investigator: Katrine Hordnes, MD NTNU