Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery (TRIMRIPC)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01308138
Recruitment Status : Completed
First Posted : March 3, 2011
Last Update Posted : August 20, 2015
St. Olavs Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Brief Summary:
The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

Condition or disease Intervention/treatment Phase
Myocardial Injury Behavioral: Exercise training Procedure: remote ischemic preconditioning Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function
Study Start Date : January 2011
Actual Primary Completion Date : May 2013
Actual Study Completion Date : July 2013

Arm Intervention/treatment
Experimental: ExerciseTr Behavioral: Exercise training
exercise training
Experimental: Remote ischemic preconditioning group Procedure: remote ischemic preconditioning
remote ischemic preconditioning
No Intervention: Control patient group

Primary Outcome Measures :
  1. Mitochondrial respiration [ Time Frame: 1 hour ]
    Oxygraph (Strathkelvin)

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients undergoing coronary heart surgery and heart transplantation

Exclusion Criteria:

  • myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01308138

Norwegian University of Science and Technology, Medical Faculty
Trondheim, Sør-Trondelag, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
St. Olavs Hospital
Principal Investigator: Katrine Hordnes, MD NTNU