Electronic Nose for Diagnosis of Neurodegenerative Diseases Via Breath Samples

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01291550
Recruitment Status : Unknown
Verified September 2010 by Rambam Health Care Campus.
Recruitment status was:  Recruiting
First Posted : February 8, 2011
Last Update Posted : February 8, 2011
Technion, Israel Institute of Technology
Information provided by:
Rambam Health Care Campus

Brief Summary:

The diagnosis of neurodegenerative conditions and ADHD still mostly relies on clinical symptoms as there are no validated, inexpensive, and simple bio- markers available yet. The purpose of this study is to deliver a proof-of-concept for novel biomarkers to identify neurodegenerative conditions and ADHD based on breath testing.

Alveolar breath will be collected from healthy volunteers, patients with extrapyramidal conditions, patients diagnosed with dementia and from ADHD subjects. The discriminative power of a tailor-made Nanoscale Artificial Nose (™NA-NOSE) containing an array of six nanomaterial-based sensors will be tested. Discriminant factor analysis will be applied to the NA-NOSE signals in order to detect statistically significant differences between the sub-populations, and classification success will be estimated using leave-one-out cross-validation. The identification of NA-NOSE patterns will be supported by analyzing the chemical composition of the breath using gas-chromatography in conjunction with mass-spectrometry (GC-MS).

Condition or disease
Neurodegenerative Diseases

Study Type : Observational
Estimated Enrollment : 300 participants
Time Perspective: Prospective
Study Start Date : September 2010

Resource links provided by the National Library of Medicine

Nerodegenerative diseases
Patients with parkinsonism and patients with dementia
Subjects diagnosed with ADHD

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Out patient clinic patients diagnosed with neurodegenerative conditions healthy control and subjects diagnosed with ADHD.

Inclusion Criteria:

  • Patients diagnosed with neurodegenerative conditions
  • Healthy subjects
  • Subjects diagnosed with ADHD

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01291550

Cognitive Neurology, Rambam Medical Center Recruiting
Haifa, Israel, 31096
Contact: Judith Aharon-Peretz, M.D    97248543190   
Contact: Michal Levavi, MA.RN         
Principal Investigator: Judith Aharon-Peretz, M.D         
Sponsors and Collaborators
Rambam Health Care Campus
Technion, Israel Institute of Technology

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Prof Judith aharon-Peretz, Rambam Medica Center Identifier: NCT01291550     History of Changes
Other Study ID Numbers: 0196-09
First Posted: February 8, 2011    Key Record Dates
Last Update Posted: February 8, 2011
Last Verified: September 2010

Keywords provided by Rambam Health Care Campus:
Detecting volatile biomarkers using breath sample

Additional relevant MeSH terms:
Neurodegenerative Diseases
Nervous System Diseases