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Aqueous Humor Dynamics and Biometric Parameters in Eyes of Children

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2016 by University of Nebraska
Information provided by (Responsible Party):
Carol B. Toris, BA MS PhD, University of Nebraska Identifier:
First received: February 3, 2011
Last updated: May 10, 2016
Last verified: May 2016
The purpose of this study is to determine the effect of age and ethnic background on ocular aqueous humor dynamics and biometric parameters. Data of normal healthy children and adults will be used as controls for future study of juvenile glaucoma, and diabetes and potentially for any other condition that affects intraocular pressure in children.

Normal Drug Tolerance

Study Type: Observational
Study Design: Observational Model: Cohort
Official Title: Aqueous Humor Dynamics and Biometric Parameters in Eyes of Children

Further study details as provided by University of Nebraska:

Estimated Enrollment: 144
Study Start Date: June 2013
Estimated Study Completion Date: July 2019
Estimated Primary Completion Date: July 2018 (Final data collection date for primary outcome measure)
Children of Caucasian descent
Healthy children of Caucasian descent.
Adults of Caucasian descent
Healthy adult eyes of Caucasian descent.
Children of African-American descent
Healthy children of African-American descent.
Adults of African-American descent
Healthy adults of African-American descent.

  Show Detailed Description


Ages Eligible for Study:   15 Years to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
  • Children
  • Adults
  • Caucasian or African American

Inclusion Criteria:

  • Subjects must not have any ocular diseases
  • Children, 15 - 18 years of age
  • Adults, 30 - 50 years of age

Exclusion Criteria:

  • Women who are pregnant or lactating
  • Aphakia or pseudophakia
  • Chronic or recurrent severe ocular inflammatory disease.
  • Ocular infection or inflammation within three (3) months of screening visit.
  • History of clinically significant or progressive retinal disease such as retinal degeneration, diabetic retinopathy or retinal detachment.
  • Any abnormality preventing reliable tonometry of either eye.
  • History of any ocular pathology (including dry eye).
  • A cup-to-disc ratio greater than 0.8
  • History of intraocular surgery
  • History of ocular laser surgery
  • History of hypersensitivity or allergy to beta blockers and sulfa drugs.
  • History of severe, unstable or uncontrolled cardiovascular, hepatic or renal disease.
  • History of bronchial asthma or chronic obstructive pulmonary disease (COPD).
  • Inability to discontinue contact lens wear.
  • Diagnosis of ocular hypertension or glaucoma or any ocular disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01290588

Contact: Carol Toris, PhD 402-559-9472
Contact: Lisa Greer, MBA 402-559-1852

United States, Nebraska
University of Nebraska Medical Center, Department of Ophthalmology and Visual Sciences Recruiting
Omaha, Nebraska, United States, 68198-5540
Contact: Carol Toris, PhD    402-559-9472   
Contact: Lisa Greer, MBA    402-559-1851   
Sponsors and Collaborators
University of Nebraska
Principal Investigator: Carol Toris, PhD University of Nebraska Medical Center, Department of Ophthalmology and Visual Sciences
  More Information

Responsible Party: Carol B. Toris, BA MS PhD, Principal Investigator, University of Nebraska Identifier: NCT01290588     History of Changes
Other Study ID Numbers: 364-09-FB
Study First Received: February 3, 2011
Last Updated: May 10, 2016
Individual Participant Data  
Plan to Share IPD: Undecided
Plan Description: Data Sharing plan is yet to be finalized. processed this record on May 24, 2017