Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
Recruitment status was: Recruiting
The purpose of this study is to
- Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference.
- Evaluate parameters related to the BME of the collapsed vertebral body on DE CT virtual noncalcium images, such as the morphologic signs, visual qualitative detection, and quantitative values.
Compression Fracture of Thoracic Vertebral Body
Spinal Compression Fracture
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Use of Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures|
|Study Start Date:||January 2011|
|Estimated Study Completion Date:||December 2011|
|Estimated Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
Patients with multiple compression fractures and in those with chronic fracture, determining which vertebra to treat is frequently difficult. In such patients, the treatment location is commonly determined from findings at imaging, which includes magnetic resonance (MR) imaging, bone scintigraphy, and computed tomography (CT).
The bone marrow edema (BME) in acute/subacute VCFs is useful in determining the vertebra that is to be treated.
MR imaging provides information on anatomic vertebral collapse and the loss of normal T1 high signal intensity from the marrow space of vertebrae with acute fractures. Loss of normal T1 high signal intensity indicates the presence of BME, which is the important sign for the PVP treatment of VCFs.
Dual-energy (DE) CT has been used to create a virtual unenhanced scan by subtracting iodine from contrast agent-enhanced CT examinations.We expect that the same technique can be used to calculate a virtual noncalcium image from an unenhanced image, which makes bone marrow accessible for CT diagnosis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01281826
|National Cheng-Kung University Hospital|
|Study Chair:||Chien-Kuo Wang||Department of Diagnostic Radiology Cheng Kung University Medicial Center|