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Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01273831
First Posted: January 11, 2011
Last Update Posted: January 11, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Isfahan University of Medical Sciences
  Purpose
The purpose of this study is to determine which drug makes lower intraocular pressure

Condition Intervention Phase
Intraocular Pressure Drug: atracurium Drug: cisatracurium Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Official Title: Study of Effects of Cisatracurium and Atracurium on Intraocular Pressure

Resource links provided by NLM:


Further study details as provided by Isfahan University of Medical Sciences:

Primary Outcome Measures:
  • intraocular pressure [ Time Frame: at 2 minutes after intubation ]
    determining intraocular pressure in atracurium and cisatracurium groups


Secondary Outcome Measures:
  • systolic blood pressure [ Time Frame: at 2 minutes after intubation ]
    identification of systolic blood pressure in atracurium and cisatracurium groups


Enrollment: 90
Study Start Date: July 2009
Study Completion Date: December 2009
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
atracurium
Patients who underwent general anesthesia received atracurium
Drug: atracurium
atracurium, Drop,0.5 mg/kg, one time, one day
cisatracurium
Patients who underwent general anesthesia received cisatracurium
Drug: cisatracurium
cisatracurium, drop,0.15mg/kg,one time, one day

Detailed Description:
Increase in intraocular pressure (IOP) following tracheal intubation during general anesthesia can be troublesome. The investigators compared the influence of cisatracurium and atracurium on IOP in patients undergoing general anesthesia.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

ASA class of I or II baseline IOP of lower than 20 mmHg stable hemodynamics no history of ophthalmic diseases not using drugs affecting IOP (e.g. anticholinergics, sympathomimetics) no contraindication for atracurium or cisatracurium administration.

Exclusion Criteria:

difficulty in mask ventilation or in tracheal intubation end expiratory CO2 of below 35 mmHg or over 45 mmHg O2 saturation of below 90%

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01273831


Locations
Iran, Islamic Republic of
Al-zahra university hospital
Isfahan, Iran, Islamic Republic of
Sponsors and Collaborators
Isfahan University of Medical Sciences
Investigators
Study Chair: Mitra Jabalameri, A.Professor Associate Professor,Anesthesiology department
  More Information

Additional Information:
Responsible Party: Dr. Alireza Yousefy/Associate Professor of Medical Education, Isfahan University of Medical Sciences
ClinicalTrials.gov Identifier: NCT01273831     History of Changes
Other Study ID Numbers: ASD-1213-10
First Submitted: January 10, 2011
First Posted: January 11, 2011
Last Update Posted: January 11, 2011
Last Verified: July 2009

Keywords provided by Isfahan University of Medical Sciences:
intraocular pressure, anesthesia,cisatracurium,atracurium.

Additional relevant MeSH terms:
Anesthetics
Cisatracurium
Atracurium
Central Nervous System Depressants
Physiological Effects of Drugs
Neuromuscular Blocking Agents
Neuromuscular Agents
Peripheral Nervous System Agents
Neuromuscular Nondepolarizing Agents
Nicotinic Antagonists
Cholinergic Antagonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action