Retrospective Study of Ovarian Cancer Patients With Brain Metastasis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01258881
Recruitment Status : Unknown
Verified December 2010 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : December 13, 2010
Last Update Posted : December 13, 2010
Information provided by:
National Taiwan University Hospital

Brief Summary:
Ovarian cancer, especially epithelial ovarian carcinoma, has the highest mortality rate among the gynecologic malignancies. The majority of patients with epithelial ovarian carcinoma are diagnosed at advanced stage which has the overall survival rates of only 19-30%. As the advance in the managements which prolonged the overall survival, metastatic lesion in rare location such as brain was noted in few patients of ovarian cancer in recent years. In the retrospective study, the investigators will review the medical records of the ovarian cancer patients with brain metastasis in the investigators hospital to investigate the incidence, clinical courses, optimal managements and possible prognostic factors in the rare condition.

Condition or disease
Ovarian Cancer Brain Metastases

Detailed Description:
The ovarian cancer patient treated at the Department of Obstetrics and Gynecology of the National Taiwan University Hospital were retrospectively collected. The cancer registration database was searched for the patients with ovarian carcinoma who brain metastases were also diagnosed. The medical records of these patients were reviewed with particular attention to the results of histo-pathological and radiologic reports. Patients with other synchronous primary brain tumor were excluded. The initial management of primary tumor, including the surgery and adjuvant chemotherapy, and the clinical courses and disease status, such as remission, recurrence and progression, were all carefully reviewed. The intra-cranial lesions were all diagnosed by imaging studies, including brain computed tomography (CT) and magnetic resonance imaging (MRI) scans. Therapeutic strategies for the metastatic lesions in the brain were also reviewed. All statistical analyses were performed using the SPSS 13.0 statistical software for Windows. P<0.05 was defined as statistical significance. Survival was measured from the time of initial diagnosis of brain metastasis until the date of death or last contact, and was presented by Kaplan-Meier curves.

Study Type : Observational
Estimated Enrollment : 70 participants
Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Retrospective Study of Ovarian Cancer Patients With Brain Metastasis
Study Start Date : April 2010
Estimated Primary Completion Date : December 2010
Estimated Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Ovarian Cancer
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
ovarian cancer patients with brain metastasis

Inclusion Criteria:

  • Patients with ovarian cancer and brain metastasis
  • Patients ovarian cancer from National Taiwan University Hospital

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01258881

Contact: Wen-Fang Cheng, Professor 886-2-23123456 ext 71964

National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Wen-Fang Cheng, Professor    886-2-23123456 ext 71964   
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Wen-Fang Cheng, Professor National Taiwan University Hospital

Responsible Party: Wen-Fang Cheng/Professor, National Taiwan University Hospital Identifier: NCT01258881     History of Changes
Other Study ID Numbers: 201004066R
First Posted: December 13, 2010    Key Record Dates
Last Update Posted: December 13, 2010
Last Verified: December 2010

Additional relevant MeSH terms:
Neoplasm Metastasis
Ovarian Neoplasms
Brain Neoplasms
Neoplastic Processes
Pathologic Processes
Endocrine Gland Neoplasms
Neoplasms by Site
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Central Nervous System Neoplasms
Nervous System Neoplasms
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases