Expanding Rapid Ascertainment Network of Schizophrenia Families in Taiwan

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01249079
Recruitment Status : Unknown
Verified October 2010 by China Medical University Hospital.
Recruitment status was:  Recruiting
First Posted : November 29, 2010
Last Update Posted : December 1, 2010
National Taiwan University Hospital
Information provided by:
China Medical University Hospital

Brief Summary:

This proposal responds to Request for Applications RFA-MH-08-131, which seeks applications that propose to enrich pre-existing resources for schizophrenia in the National Institute of Mental Health (NIMH) Human Genetics Initiative and to apply genomic methods to further the investigators understanding of the molecular etiology of the disorder. The overarching aims of this proposal are to quickly and cost-effectively ascertain a large sample of trio families affected by schizophrenia, and to discover causal variants for the disorder in the first family-based genome-wide association study (GWAS) of the disorder. In Taiwan, there is no such kind of policy to support this kind of GWAS study as it is a very expensive study, including collecting large family samples and genome-wide single-nucleotide polymorphism (SNP) scanning. The investigators, thus, collaborate with Professor Ming T, Tsuang and his entended subcontracted researchers to apply for this project. The investigators, the research team in Taiwan, will collect 3800 trio families (11400 subjects) of schizophrenia. Through additional ascertainment within this framework, the investigators will collect an aggregate sample with adequate power for detecting in a GWAS those variants that make even small contributions to the risk for the disorder.

The investigators will meet the overarching goals of this project by accomplishing several Specific Aims, as follows: 1) Rapidly ascertain schizophrenia trio families from Taiwanese clinical ascertainment sites; 2) Supplement NIMH Genetics Initiative collections by sending all clinical data and biomaterials to the appropriate repositories; 3) Assess the association of schizophrenia with a genome-wide panel of single-nucleotide polymorphisms (SNPs) and their constituent haplotypes; 4) Analyze quantitative schizophrenia phenotypes such as age at onset ; 5) Perform a genome-wide survey for copy-number variations related to schizophrenia; 6) Test for gene-gene interactions (epistasis); and 7) Test for gene-environment interactions, such as the well-established effect of season of birth.

Condition or disease Intervention/treatment
Schizophrenia Other: No intervention would be provided in this research

Study Type : Observational
Estimated Enrollment : 600 participants
Observational Model: Family-Based
Official Title: Expanding Rapid Ascertainment Network of Schizophrenia Families in Taiwan
Study Start Date : October 2010
Estimated Primary Completion Date : December 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Group/Cohort Intervention/treatment
Schizophrenia Family Other: No intervention would be provided in this research
No intervention would be provided in this research,but need to draw blood

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Schizophrenia patients and their biological parents

Inclusion Criteria:

  • clinical diagnosis of schizophrenia and their parents, and parents are still alive

Exclusion Criteria:

  • person with Mental Retardation
  • persons with epilepsy
  • alcohol or substance abuse combined
  • in combination with other organic brain damage syndrome

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01249079

Contact: Hai-Gwo Hwu 886-2-23122453 ext 66785

China Medical University Hospital Recruiting
Taichung, Taiwan
Contact: Hsien-Yuan Lane         
Sponsors and Collaborators
China Medical University Hospital
National Taiwan University Hospital
Study Director: Hsien-Yuan Lane China Medical University Hospital

Responsible Party: Hsien-Yuan Lane,Chief of Psychiatry Department, China Medical University Hospital Identifier: NCT01249079     History of Changes
Other Study ID Numbers: DMR99-IRB-214
First Posted: November 29, 2010    Key Record Dates
Last Update Posted: December 1, 2010
Last Verified: October 2010

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders