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The Use of 2D and 3D Imaging Modalities and Its Influence on Diagnosis and Treatment Planning in Orthodontics

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ClinicalTrials.gov Identifier: NCT01246830
Recruitment Status : Completed
First Posted : November 23, 2010
Last Update Posted : December 3, 2014
Katholieke Universiteit Leuven
Information provided by (Responsible Party):
Universitaire Ziekenhuizen Leuven

Brief Summary:

Research questions:

  1. Will the panoramic images derived from cone beam CT data give better diagnostic ability than conventional panoramic radiographs?
  2. Will 3D cephalometric analysis offer the orthodontists and surgeons better information for treatment planning?
  3. Will the 3D cephalometric analysis give more accurate treatment plan and better treatment outcome?

General hypothesis and special aims

Overall aims:

  • To compare 2D versus 3D cephalometric analysis: treatment planning and therapeutic outcome.
  • To determine the accuracy and diagnostic ability and usability of the 3D cephalometric analysis.
  • To evaluate the diagnostic ability and usability of the panoramic image derived from cone beam CT data as compared to 2D panoramic images.
  • To evaluate the value of the cone beam CT data in cephalometric analysing process for orthodontic and maxillofacial surgery treatment.


  1. The availability of the 3D cephalometric analysis influences the orthodontic and maxillofacial treatment plan and decision, and might change the treatment outcome.
  2. Panoramic images derived from cone beam CT data may provide equal information for diagnosis as conventional panoramic images.
  3. Cone beam CT will be able to replace "classic orthodontic imaging" being more time and dose efficient and having a beneficial effect on treatment outcome.

Condition or disease Intervention/treatment
Orthodontics Malocclusion Impacted Tooth Cephalometry Cone-Beam Computed Tomography Panoramic Radiography Radiation: Panoramic radiograph, Cephalometric radiograph Radiation: Cone-beam computed tomography (CBCT)

Study Type : Observational
Actual Enrollment : 32 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Use of 2D and 3D Imaging Modalities and Its Influence on Diagnosis and Treatment Planning in Orthodontics
Study Start Date : January 2012
Primary Completion Date : December 2013
Study Completion Date : September 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Orthodontia
U.S. FDA Resources

Group/Cohort Intervention/treatment
3D cephalometric analysis Radiation: Cone-beam computed tomography (CBCT)
CBCT data will be used in 3D cephalometric analysis softwares
2D cephalometric analysis Radiation: Panoramic radiograph, Cephalometric radiograph
2D images that are used for orthodontic treatment planning

Primary Outcome Measures :
  1. Cephalometric analysis [ Time Frame: at treatment planning step and after 2 years of treatment ]
    linear and angular cephalometric measurement

Secondary Outcome Measures :
  1. outcome of orthodontic treatment [ Time Frame: after 2 years of treatment ]

Information from the National Library of Medicine

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Ages Eligible for Study:   12 Years to 25 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who are seeking orthodontic and maxillofacial surgery treatments at the University Hospital Leuven with the need of conventional panoramic radiographs, cephalometric radiographs and cone beam CT images.

Inclusion Criteria:

  • age 12-25 years old
  • Patients with malocclusions
  • Patients with jaw relation defect both with or without the need of orthognathic surgery
  • Patients with maxillofacial defects: tumors and trauma
  • Patients with eruption problems: embedded or impacted teeth which have to be removed

Exclusion Criteria:

  • Patients with congenital deformities
  • Patients with systemic diseases that may effect the growth formation: growth factor defect and thyroid hormone defect.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01246830

Katholieke Universiteit Leuven
Leuven, Belgium, 3000
University Hospital Leuven
Leuven, Belgium, 3000
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
Katholieke Universiteit Leuven

Broadbent BH. A new x-ray technique and its application to orthodontia. Angle Orthodontist 1931;51: 115-150
Proffit WR, Fields HW Jr., Sarver DM. Contemporary Orthodontics. 4th ed, Mosby Inc., Elsevier Science, Philadelphia, 2006.

Responsible Party: Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier: NCT01246830     History of Changes
Other Study ID Numbers: S52731
First Posted: November 23, 2010    Key Record Dates
Last Update Posted: December 3, 2014
Last Verified: September 2010

Additional relevant MeSH terms:
Tooth, Impacted
Tooth Diseases
Stomatognathic Diseases