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The Effect of Artificial Sweeteners on Blood Glucose Response

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ClinicalTrials.gov Identifier: NCT01246492
Recruitment Status : Withdrawn
First Posted : November 23, 2010
Last Update Posted : May 18, 2012
Sponsor:
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to determine whether the presece of the artificial sweeteners aspartame, saccharin and asceulfame-k affect the blood glucose responses to an orally incested glucose solution.

Condition or disease Intervention/treatment
Taste Receptors Nutrient Sensing Intestinal Absorption Blood Glucose Appetite Dietary Supplement: Artificial Sweeteners

Detailed Description:
Sweet taste receptors, similar to those located on the lingual taste buds have been located along in the lining of the gut. Recent studies have demonstrated that activation of these sweetness taste receptors, either by sugars such as glucose, fructose, lactose, or artificial sweeteners such as saccharin and aspartame can influence the way nutrients, including glucose are absorbed from the gut into the bloodstream. Studies in animal models have shown that activation of the sweet taste receptors can increase the expression of the sodium-dependant glucose transporter 1 (SGLT1) and glucose transporter 2 (GLUT2) which transport glucose from the lumen into the bloodstream. Thus providing a potential mechanism by which glucose uptake can be regulated. Although artificial sweeteners stimulate the sweet taste receptors, they have little nutritive value, so that when they are consumed in the absence of any other nutrients there is little effect on blood glucose response. However, the effects of consuming artificial sweeteners in combination with sugars such as glucose is unclear. The purpose of this study is to investigate whether the addition of artificial sweeteners to an orally consumed glucose solution affects the rate at which the glucose appears in the blood.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 0 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: The Effect of Artificial Sweeteners on Blood Glucose Response
Study Start Date : November 2010
Estimated Primary Completion Date : May 2011
Estimated Study Completion Date : May 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Blood Sugar
Drug Information available for: Dextrose
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Placebo Comparator: 45g glucose
glucose water
Dietary Supplement: Artificial Sweeteners
A 400mL drink sweetened with 45g glucose and artificial sweetener will be consumed orally
Active Comparator: 45g glucose + 150mg aspartame
glucose water aspartame
Dietary Supplement: Artificial Sweeteners
A 400mL drink sweetened with 45g glucose and artificial sweetener will be consumed orally
Active Comparator: 45g glucose + 20 mg saccharin
glucose water saccharin
Dietary Supplement: Artificial Sweeteners
A 400mL drink sweetened with 45g glucose and artificial sweetener will be consumed orally
Active Comparator: 45g glucose + 85mg asculfame - K
glucose water aseulfame- k
Dietary Supplement: Artificial Sweeteners
A 400mL drink sweetened with 45g glucose and artificial sweetener will be consumed orally


Outcome Measures

Primary Outcome Measures :
  1. Blood glucose response [ Time Frame: 90 min ]
    Blood glucose will be determined at baseline and for 90 min following the consumption of the test drinks


Secondary Outcome Measures :
  1. Subjective appetite [ Time Frame: 90 min ]
    Subjective appetite ratings will be collected at baseline and for 90 min following the consumption of the test drinks


Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy subjects
  • Aged 18-45 years
  • BMI (19-25 kg/m2)
  • Weight stable in past 3 months

Exclusion Criteria:

  • Smoking
  • Females who are pregnant of breastfeeding
  • Regular intake of emdication, other than females taking oral contraceptives
  • Medical illness
  • Gastrointestinal disorders
  • Food allergies
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01246492


Locations
United Kingdom
Brain, Performance and Nutrition Research Centre- Northumbria University
Newcastle-Upon Tyne, United Kingdom, NE1 8ST
Sponsors and Collaborators
Northumbria University
Investigators
Principal Investigator: Nerys M Astbury, PhD Northumbria University
More Information

Responsible Party: Brain, Performance and Nutrition Research Centre, Northumbria University
ClinicalTrials.gov Identifier: NCT01246492     History of Changes
Other Study ID Numbers: 34AK1
First Posted: November 23, 2010    Key Record Dates
Last Update Posted: May 18, 2012
Last Verified: May 2012