Immune Responses to Yellow Fever Vaccine

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2016 by Emory University
Information provided by (Responsible Party):
Sri Edupuganti, MD MPH, Emory University Identifier:
First received: November 18, 2010
Last updated: February 3, 2016
Last verified: February 2016
The objective of this study is to study immune memory generated against the yellow fever (YFV) vaccine in participants who have previously received the vaccine. Volunteers will not receive vaccine shots; only immune responses to previous yellow fever vaccination will be studied. The study involves one or multiple blood draws.

Yellow Fever Vaccine

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Characterization of Human Memory Immune Responses to Prior Yellow Fever Vaccination

Resource links provided by NLM:

Further study details as provided by Emory University:

Primary Outcome Measures:
  • Determine the phenotypic and functional characterization of memory T cell responses to YF vaccination [ Time Frame: Immune responses will be measured from at least 30 days after yellow fever vaccination. ] [ Designated as safety issue: No ]
    This is an exploratory analysis of variation in immune response with time since last yellow fever virus vaccination.

Biospecimen Retention:   Samples With DNA

Estimated Enrollment: 100
Study Start Date: November 2010
Estimated Study Completion Date: August 2020
Estimated Primary Completion Date: August 2020 (Final data collection date for primary outcome measure)
Group 1: 18 to 45 years of age
Group 2: 55 years of age and above


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy adults between the ages of 18 to 45 years or 55 or above who previously received the yellow fever vaccine

Inclusion Criteria:

  1. Able to understand and give informed consent
  2. Age 18-45 years (Group 1) or 55 years and above (group 2) at the time of yellow fever vaccination
  3. Documentation (international certificate of vaccination (yellow card) or medical record) indicating receipt of yellow fever vaccine.

Exclusion Criteria:

  • 1. Recipient of any vaccines within 30 days before the study visit (not applicable to older adults) 2. History of a progressive and severe chronic medical condition resulting in impaired immunity (such as diabetes, kidney or liver dysfunction) 3. Required use of immunosuppressive medications 4. Reporting HIV, Hepatitis B (surface antigen positive) or Hepatitis C infections (antibody positive) on the medical/health history form 5. Recipient of a blood product or immune globulin product within 42 days of study visit 6. Reporting pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01244802

Contact: Shashi Nagar, RN 404-712-1370

United States, Georgia
The Hope clinic of Emory Vaccine Center Recruiting
Decatur, Georgia, United States, 30030
Contact: Sashi Nagar   
Principal Investigator: Srilatha Edupuganti, MD         
Sponsors and Collaborators
Emory University
Study Director: Rafi Ahmed, PhD Emory University
Principal Investigator: Srilatha Edupuganti, MD Emory University
  More Information

Responsible Party: Sri Edupuganti, MD MPH, Assistant Professor, Emory University Identifier: NCT01244802     History of Changes
Other Study ID Numbers: IRB00002834  YFV-2 Cross sectional 
Study First Received: November 18, 2010
Last Updated: February 3, 2016
Health Authority: United States: Federal Government

Keywords provided by Emory University:
yellow fever vaccine

Additional relevant MeSH terms:
Yellow Fever
Arbovirus Infections
Body Temperature Changes
Flaviviridae Infections
Flavivirus Infections
Hemorrhagic Fevers, Viral
RNA Virus Infections
Signs and Symptoms
Virus Diseases processed this record on May 04, 2016