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Exercise-induced Bronchoconstriction Diagnostics: Impact of a Repeated Exercise Challenge Test
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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The purpose of this study is to increase the knowledge of the possible diagnostic effect of exercise induced bronchoconstriction performing a repeated exercise challenge test.
Condition or disease
Exercise Induced Bronchoconstriction
Prior studies have shown that the intensity influences the sensitivity of exercise challenge tests (ECT) and that a heart rate-based protocol does not ensure sufficient exercise intensity to induce bronchoconstriction. It is not common clinical practice to perform a pre ECT to establish maximal heart rate or maximal oxygen uptake. The heart rate formula recommended by ATS (HRmax= 220−age) is usually applied to determine recommended intensity of the ECT. Conducting a second ECT, based on the knowledge of the first test, introduce the possibility to adjust the intensity on an individual basis. In addition, based on clinical experience, patients may seem reluctant to perform maximal the first time they undergo an ECT on a treadmill. The hypothesis is that patients are less reluctant to perform maximal the second time they undergo the test when they are more accustomed to the procedure and the treadmill by itself.
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Ages Eligible for Study:
16 Years to 45 Years (Child, Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Subjects referred to Klinikk for allergi og luftveissykdommer
Referred to Klinikk for allergi og luftveissykdommer
Meet at least 3 out of 5 criteria (symptoms related to exercise):
Cough during exercise or within 5 minutes after exercise
Wheeze during exercise or within 5 minutes after exercise
Heavy breathing, expiratory in particular, during exercise or within 5 minutes after exercise (duration 5 minutes or more)
Improvement of physical fitness/breath is lacking despite of exercise intensification
Chest tightness during or after exercise
Patients former diagnosed with-and treated for asthma who have symptoms of EIB are included in the study.
Ongoing respiratory infection or recent respiratory infection, judged by the responsible doctor to be of importance of the result
The inability to perform an Exercise challenge test with maximum effort
Angell MR, Augestad LB, Haugen TS, Frostad A, Grønnerød TA, Stensrud T. Exercise-induced bronchoconstriction diagnostics: Impact of a repeated exercise challenge test. Open Journal of Respiratory Diseases 4:55-63, 2014 http://file.scirp.org/pdf/OJRD_2014043017202072.pdf