Environmental & Genetic Influences on Vitamin D Status
The purpose of this study is to determine the effect of environmental and genetic influences on Vitamin D status.
Vitamin D Deficiency
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Environmental & Genetic Influences on Vitamin D Status|
- 25(OH)D levels [ Time Frame: 1 month ] [ Designated as safety issue: No ]25(OH)D levels were measured at the only visit
- Genetic testing of 13 candidate genes [ Time Frame: 1 month ] [ Designated as safety issue: No ]13 candidate genes were tested and their relationship to 25(OH)D examined.
Biospecimen Retention: Samples With DNA
Blood was obtained for genetic testing of selected 13 candidate genes important for vitamin D metabolism
|Study Start Date:||August 2010|
|Study Completion Date:||August 2010|
|Primary Completion Date:||August 2010 (Final data collection date for primary outcome measure)|
Sun exposed people
Sun exposure >3 hours daily for at least 5 days weekly for the last 3 months.
Vitamin D deficiency is a common problem. The principal source of vitamin D for humans is solar exposure, with cutaneous synthesis of vitamin D by photoconversion of 7-dehydrocholesterol in the skin to pre-vitamin D3. Latitude, altitude, season, skin pigmentation, and age are recognized factors that influence how much vitamin D can be made by solar exposure. Surprisingly, Vitamin D deficiency has been described in people dwelling in southern Florida and in surfers in Hawaii. We hypothesize that genetic variations in vitamin metabolism accounts for these differences.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01208636
|United States, Nebraska|
|Omaha, Nebraska, United States, 68131|
|Principal Investigator:||Laura Armas, MD||Creighton University|