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Mediators of Atherosclerosis in South Asians Living in America (MASALA)

This study is ongoing, but not recruiting participants.
Northwestern University
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Alka Kanaya, University of California, San Francisco Identifier:
First received: September 21, 2010
Last updated: May 14, 2015
Last verified: May 2015
South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asians at two United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. The purpose of this study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those in other United States ethnic groups.

Cardiovascular Diseases
Heart Diseases
Coronary Artery Disease
Coronary Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Mediators of Atherosclerosis in South Asians Living in America

Resource links provided by NLM:

Further study details as provided by University of California, San Francisco:

Primary Outcome Measures:
  • Coronary artery calcium prevalence in South Asians [ Time Frame: Baseline ]

Secondary Outcome Measures:
  • Carotid intima media thickness [ Time Frame: Baseline ]
  • Diabetes Prevalence [ Time Frame: Baseline ]
  • Change from baseline Coronary artery calcium prevalence in South Asians at 4 years [ Time Frame: Baseline to Year 4 ]
  • Incidence of type 2 diabetes after approximately 4 years of follow-up [ Time Frame: Baseline to Year 4 ]

Enrollment: 906
Study Start Date: September 2010
Primary Completion Date: March 2013 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   40 Years to 79 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
South Asians (individuals from India, Pakistan, Nepal, Bangladesh, and Sri Lanka) adults between the ages of 40 and 79 years without cardiovascular disease living in the San Francisco Bay Area and Chicago Area.

Inclusion Criteria:

  • South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka
  • age between 40 and 79 years.

Exclusion Criteria:

  • Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin)
  • Current atrial fibrillation
  • Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries)
  • Active treatment for cancer
  • Life expectancy less than 5 years due to serious medical illness
  • Impaired cognitive ability as judged by the reviewer
  • Plans to move out of the study region in next 5 years
  • Weight greater than 300 pounds
  • Living in a nursing home or on a waiting list
  • Unable to speak/read/write English, Hindi or Urdu
  Contacts and Locations
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Please refer to this study by its identifier: NCT01207167

United States, California
University of California, San Francisco
San Francisco, California, United States, 94115
United States, Illinois
Northwestern University
Chicago, Illinois, United States, 60611
Sponsors and Collaborators
University of California, San Francisco
Northwestern University
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Alka Kanaya, MD University of California, San Francisco
Principal Investigator: Namratha Kandula, MD Northwestern University
  More Information

Responsible Party: Alka Kanaya, Professor, University of California, San Francisco Identifier: NCT01207167     History of Changes
Other Study ID Numbers: MASALA
R01HL093009 ( US NIH Grant/Contract Award Number )
Study First Received: September 21, 2010
Last Updated: May 14, 2015

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Arterial Occlusive Diseases
Vascular Diseases processed this record on April 28, 2017