Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis Patients
|ClinicalTrials.gov Identifier: NCT01202045|
Recruitment Status : Withdrawn
First Posted : September 15, 2010
Last Update Posted : July 8, 2013
|Condition or disease|
|Scleroderma, Systemic Hypertension, Pulmonary|
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Official Title:||Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis Patients With Indirect Signs of Pulmonary Arterial Hypertension|
|Study Start Date :||September 2010|
|Actual Primary Completion Date :||October 2011|
|Estimated Study Completion Date :||October 2011|
systemic sclerosis patients
Every patient will have a rest echocardiography, a stress echocardiography, a right heart catheterization, a blood specimen, and a pulmonary function test.
- Correlation of a 20 mmhg increase in the pulmonary artery pressures (PAP) during stress echocardiography and PAP using right heart catheterization. [ Time Frame: 5 years ]Every patient will have both procedures; stress echocardiography and right heart catheterization. A positive stress echocardiography is defined as >= 20 mmhg increase in the systolic pulmonary artery pressure (SPAP) (between rest and stress) or an absolute value >= 55 mmhg. A positive right heart catheterization at rest is defined as a PAPm >25mmhg, wedge < 18 and pulmonary vascular resistances >3 wood units. Stress catheterization will also be perform and is defined as a PAPm > 30mmhg and wedge <18 mm hg.
- Correlation of a 20 mmhg increase in the PAP during stress echocardiography and elevated NT-proBNP. [ Time Frame: 5 years ]
- Function of the left ventricle (left ventricular ejection fraction) at rest and at stress. [ Time Frame: Follow up every year X 5 ]We hypothesize that patients who do not increase their left ventricular ejection fraction at stress have a worst clinical outcome in the follow up.
- Diastolic function at rest and at stress [ Time Frame: follow up every year X 5 ]We hypothesize that patients with diastolic dysfunction manifesting at stress have a worst clinical outcome in the follow up.
- Function of the right ventricle [ Time Frame: Follow up every year X 5 ]We hypothesise that in patients with or without pulmonary hypertension, right ventricular dysfunction is associated with a worse clinical outcome
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01202045
|Centre hospitalier universitaire de Sherbrooke|
|Sherbrooke, Quebec, Canada, J1H 5N4|
|Principal Investigator:||Paul Farand, md, msc||Centre de recherche du Centre hospitalier universitaire de Sherbrooke|