Impact of Physical Activity on Left Ventricular Mass and Lipid Metabolism
Prospective study on the structural and functional changes in the heart of adult women assessed by echocardiogram and in lipid metabolism that occur in response to physical training. Using echocardiogram we will characterize the early determinants of "athletic remodeling". We will also assess the effect of intense physical training on lipid metabolism, focus on HDL subspecies and function.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Impact of Physical Activity on Left Ventricular Mass and Lipid Metabolism in Healthy Female Volunteers Training for a Marathon|
- Lipid Metabolism [ Time Frame: Baseline, In-Training, Post-training (at least 6 weeks after the race) ] [ Designated as safety issue: No ]
- Heart architecture and function [ Time Frame: Baseline, In-training, Post-training ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||February 2011|
|Estimated Study Completion Date:||January 2016|
|Estimated Primary Completion Date:||June 2015 (Final data collection date for primary outcome measure)|
Exercise training, women, marathon.
Other: prospective study with no intervention
Other: Exercise training, women, marathon
Prospective study with no intervention in women who have volunteered to run a full marathon or a half-marathon. Each subject will serve as own control. Each subject will be studies at 3 stages: baseline, after at least 12 weeks of training for the marathon (we will not provide training), 6 weeks after running the marathon.
Left ventricular hypertrophy, defined as an increase in the mass of the left ventricle may occur as a physiologic response to exercise (athletic remodeling aka "athletic heart"), but is most frequently encountered as a pathological manifestation of cardiovascular disease. The early determinants of athletic remodeling in the general population are largely unknown. In order to longitudinally explore the early determinants of athletic remodeling, we will recruit from the community, physically untrained women who have volunteered to run a marathon. We will prospectively assess left ventricular mass and function by echocardiogram during three consecutive stages/visits:
- Baseline: prior to starting intense physical training
- Trained: at the end of at least 12 week training period, prior to running the marathon.
- Post-marathon: 6 weeks after running the marathon.
In addition, exercise impacts lipid metabolism and short-term exercise is known to increase HDL levels in plasma. Human HDL is structurally heterogeneous, comprising at least sixteen discrete species. It has multiple functions, pertinent to cardiovascular medicine such as the ability to accept effluxed cholesterol from the artery wall, culminating in sterol uptake in the liver. This "reverse cholesterol transport pathway" is thought to prevent the accumulation of cholesterol in the artery wall. We will assess the clinical and genetic determinants of the HDL response to physical exercise.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01199211
|United States, California|
|CTSI - University of California San Francisco|
|San Francisco, California, United States, 94143|
|Principal Investigator:||Elyse Foster, MD||University of California, San Francisco|
|Principal Investigator:||John Kane, MD||University of California, San Francisco|