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Evaluation of Surfactant Protein B in the Differential Diagnostics of Dyspnea

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ClinicalTrials.gov Identifier: NCT01197586
Recruitment Status : Completed
First Posted : September 9, 2010
Last Update Posted : June 24, 2013
Sponsor:
Collaborator:
Roche Diagnostics
Information provided by (Responsible Party):
Joachim Saur, University Hospital Mannheim

Brief Summary:
Establishing new biochemical markers in the differential diagnostics and risk stratification in heterogeneous patient collectives is becoming more and more important. The markers should be objective, reliable, reproducible, quick and cost effective as well as specific and sensitive. Concerning the differential diagnostics of "dyspnea", NT-pro-BNP plays the most important role for the evaluation of a cardiac origin. However, a corresponding biochemical marker for pulmonary stress is lacking. The aim of the study at hand therefore was the evaluation of surfactant protein B in the differential diagnostics of pulmonary and cardiac diseases.

Condition or disease
Dyspnea Cardiac Disease Pulmonary Disease

Study Type : Observational
Actual Enrollment : 55 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : October 2010
Actual Primary Completion Date : December 2011
Actual Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. Surfactant protein B serum levels [ Time Frame: Days 1, 3 and 7 ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients presenting with the symptom "dyspnea" in a university hospital emergency room
Criteria

Inclusion Criteria:

  • patients presenting with dyspnea and giving informed consent

Exclusion Criteria:

  • outpatients
  • lack or doubt of legal competence
  • indication for mechanical ventilation
  • pregnancy
  • palliative patients
  • CPAP/LTOT
  • BMI > 30 kg/m2
  • sepsis
  • anemia
  • dialysis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01197586


Locations
Germany
Universitaetsmedizin Mannheim
Mannheim, Germany, 68167
Sponsors and Collaborators
Universitätsmedizin Mannheim
Roche Diagnostics
Investigators
Principal Investigator: Joachim Saur, MD Universitätsmedizin Mannheim

Responsible Party: Joachim Saur, Principal Investigator, University Hospital Mannheim
ClinicalTrials.gov Identifier: NCT01197586     History of Changes
Other Study ID Numbers: 2010_spb_ma
First Posted: September 9, 2010    Key Record Dates
Last Update Posted: June 24, 2013
Last Verified: June 2013

Keywords provided by Joachim Saur, University Hospital Mannheim:
surfactant protein B
differential diagnostics

Additional relevant MeSH terms:
Lung Diseases
Dyspnea
Heart Diseases
Respiratory Tract Diseases
Respiration Disorders
Signs and Symptoms, Respiratory
Signs and Symptoms
Cardiovascular Diseases