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Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients
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ClinicalTrials.gov Identifier: NCT01183052
: August 17, 2010
Last Update Posted
: September 5, 2012
Centre Hospitalier Régional Universitaire Montpellier
Institut National de la Santé Et de la Recherche Médicale, France
The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.
Condition or disease
Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.
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