Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Centre Hospitalier Régional Universitaire Montpellier
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
5 Santé Identifier:
First received: August 16, 2010
Last updated: September 3, 2012
Last verified: September 2012
The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.

Condition Intervention
COPD Patients
Other: Training

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: Mitochondrial Respiratory Chain and Peripheral Muscle Dysfunction in COPD Patients

Resource links provided by NLM:

Further study details as provided by 5 Santé:

Primary Outcome Measures:
  • Cellular effects of exercise training at the ventilatory threshold intensity [ Time Frame: 6 to 8 weeks ] [ Designated as safety issue: Yes ]

Enrollment: 30
Study Start Date: June 2009
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
20 sessions of training
Other: Training
20 sessions of training
Other Name: CT

Detailed Description:
Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.

Ages Eligible for Study:   50 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Sedentary mild to severe COPD patients

Exclusion Criteria:

  • Neuromuscular disease
  • Chronic heart failure
  • Renal diseases
  • Liver diseases
  • Obesity
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Please refer to this study by its identifier: NCT01183052

Clinique du Souffle La Vallonie
Lodeve, France, 34700
Clinique du Souffle la Solane
Osseja, France, 66340
Sponsors and Collaborators
5 Santé
Centre Hospitalier Régional Universitaire Montpellier
Institut National de la Santé Et de la Recherche Médicale, France
Principal Investigator: Maurice MH Hayot, MCU-PH Institut National de la Santé Et de la Recherche Médicale, France
  More Information

Responsible Party: 5 Santé Identifier: NCT01183052     History of Changes
Other Study ID Numbers: 2009-A00426-51 
Study First Received: August 16, 2010
Last Updated: September 3, 2012
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Keywords provided by 5 Santé:
exercise tolerance
oxidative stress

Additional relevant MeSH terms:
Pulmonary Disease, Chronic Obstructive
Lung Diseases
Lung Diseases, Obstructive
Respiratory Tract Diseases processed this record on April 27, 2016