Transformation of Somatosensory and Visual Coordinate Systems

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01177462
Recruitment Status : Unknown
Verified September 2013 by Yu-Cheng Pei, Chang Gung Memorial Hospital.
Recruitment status was:  Recruiting
First Posted : August 9, 2010
Last Update Posted : September 25, 2013
Information provided by (Responsible Party):
Yu-Cheng Pei, Chang Gung Memorial Hospital

Brief Summary:
Manipulation of object is a multisensory experience that includes tactile motion between the object and the fingerpad, visual motion elicited by the motion the object and the movement of the hand, and the active motor commend to control upper limb and hand conformation. It remains to be determined how such a complex interaction between touch and vision could be achieved effortlessly. In the present study, we will investigate how the motion information is transformed between touch and vision using the most novel approaches in human psychophysics, neuropsychology and monkey neurophysiology. Specifically, we will present tactile motion on primate fingerpads using a recently developed ball stimulator with a design in which we vary the direction of motion with respect to the skin surface and also vary the hand conformation and position. This setup allows us to systematically sample the possible scenarios involving coordinate transformation between the somatosensory and visual systems in conditions that could occur in hand exploration and object manipulation in daily life. We will present these tactile stimuli on normal human subject as well as stroke patients such as patients with spatial hemineglect. Finally, we will record from macaque monkeys in cortical areas that are thought to underlie the transformation of coordinates, such as the primary somatosensory cortex and posterior parietal cortex. The results of the present study will contribute to the understanding of multisensory integration and the rehabilitation for patients with impaired use of spatial information.

Condition or disease

Study Type : Observational
Estimated Enrollment : 90 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Transformation of Coordinates Between Somatosensory and Visual Systems: a Neurophysiological Study
Study Start Date : March 2011
Estimated Primary Completion Date : December 2014

hemineglect stroke patients
Stroke patients with hemineglect
Control stroke patients
Stroke patients without hemineglect
Normal control
Normal subjects

Primary Outcome Measures :
  1. Perceived direction of tactile motion [ Time Frame: Once; specifically for stroke patients, 6 months after the onset of stroke ]

    Detail description for time frame of assessment:

    (1) for stroke patients, the assessment will be performed "in average" 6 months after the onset of stroke (2) for normal subjects: assessment will be done when the subject is willing to participate (3) the subject might come to the lab more than once if the experiment can not be completed in one session


    We present tactile motion using tactile stimulators to (1)different digits (2)different hand conformations and (3) different hand positions relative to the trunk

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We will recruit 40 normal healthy adult subjects (equal to and more than 18 years old); the exclusion criteria are subjects with brain pathology, peripheral neuropathy and limb amputation. We will also recruit 50 stroke patients, the including criteria are stroke patients with stable medical condition and being capable of receiving the evaluations. In this group, stroke patients with peripheral neuropathy, and unstable medical condition.

For stoke patients

Inclusion Criteria:

  • stroke patients
  • stable medical condition
  • can cooperate in evaluation

Exclusion Criteria:

  • peripheral neuropathy
  • limb ambulation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01177462

Chang Gung Memorial Hospital Recruiting
Taoyuan County, Taiwan, 333
Contact: Yu-Cheng Pei, MD PhD    +886-3-3281200 ext 3846   
Sponsors and Collaborators
Chang Gung Memorial Hospital
Principal Investigator: Yu-Cheng Pei, MD PhD Chang Gung Memorial Hospital

Responsible Party: Yu-Cheng Pei, Attending Physician, Chang Gung Memorial Hospital Identifier: NCT01177462     History of Changes
Other Study ID Numbers: CMRPG590021G
First Posted: August 9, 2010    Key Record Dates
Last Update Posted: September 25, 2013
Last Verified: September 2013

Keywords provided by Yu-Cheng Pei, Chang Gung Memorial Hospital:
coordinate system