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Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis

This study has been completed.
National Research Agency, France
Solvay Pharmaceuticals
Information provided by:
Institut National de la Recherche Agronomique Identifier:
First received: June 30, 2010
Last updated: NA
Last verified: May 2010
History: No changes posted
Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption. We aimed to investigate this question and assess the enzyme substitution efficiency using a sensitive method.

Condition Intervention
Drug: Creon
Other: No enzyme therapy

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Primary Purpose: Basic Science

Resource links provided by NLM:

Further study details as provided by Institut National de la Recherche Agronomique:

Primary Outcome Measures:
  • transfer of dietary nitrogen to metabolic pools

Enrollment: 11
Study Start Date: April 2005
Arms Assigned Interventions
Experimental: pancreatic enzymes Drug: Creon
Placebo Comparator: control Other: No enzyme therapy
Current enzyme therapy of the patient is stopped during 7 days


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Chronic pancreatitis
  • Pancreatic insufficiency
  • Enzyme therapy treatment

Exclusion Criteria:

  • Hepatic failure
  • Pregnancy
  • Positive serology to HIV, HCV, AGHbS, gastro-intestinal disease
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Please refer to this study by its identifier: NCT01154608

Centre de Recherche sur Volontaires
Bobigny, France, 93000
Sponsors and Collaborators
Institut National de la Recherche Agronomique
National Research Agency, France
Solvay Pharmaceuticals
  More Information

Responsible Party: Pr Benamouzig, Assistance Publique - Hôpitaux de Paris Identifier: NCT01154608     History of Changes
Other Study ID Numbers: PANCREATITE
Study First Received: June 30, 2010
Last Updated: June 30, 2010

Keywords provided by Institut National de la Recherche Agronomique:
Protein absorption in pancreatitis
Protein metabolism in pancreatitis

Additional relevant MeSH terms:
Pancreatic Diseases
Digestive System Diseases processed this record on May 22, 2017