RETRIeVE: ReversE TranscRiptase Inhibitor hiV Practice
This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Dr. Mark Bloch, Holdsworth House Medical Practice
First received: June 30, 2010
Last updated: September 8, 2013
Last verified: September 2013
An observational retrospective study of NNRTI experienced patients who have virologically failed. The study aims to assess resistance profiling and subsequent prescription patterns of patients on NNRTIs
||Time Perspective: Retrospective
||Non-nucleoside Reverse Transcriptase Inhibitor Failure in a High HIV Caseload Australian Primary Care Practice
Primary Outcome Measures:
- resistance profiling and subsequent prescription patterns of patients on NNRTIs [ Time Frame: 1 year ] [ Designated as safety issue: No ]
| Estimated Enrollment:
| Study Start Date:
| Primary Completion Date:
||September 2011 (Final data collection date for primary outcome measure)
HIV1 positive, NNRTI exposure and failure
This is a cross-sectional study involving retrospective review of HIV-1 positive patient records who began treatment with a non-nucleoside reverse transcriptase inhibitor (NNRTI) and subsequently failed. Patients who have virologically failed previous NNRTI treatment, or have resistance to 1 drug in the NNRTI class are examined further. Such patients will have attended the clinic every 3-6 months for routine medical care. The data source for variables collected is the patient's electronic medical records. This database is located at Holdsworth House Medical Practice (HHMP), Sydney.
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Demographic information will be collected from patient medical records for all patients that have used previously, or are currently using an NNRTI as part of HIV treatment therapy.
- Documented HIV infection
- Attended Holdsworth House Medical Practice 1999-2009.
- Chosen ART regime includes an NNRTI
Exclusion Criteria: N/A
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01154556
|Holdsworth House Medical Practice
|Darlinghurst, New South Wales, Australia, 2010 |
Holdsworth House Medical Practice
No publications provided
||Dr. Mark Bloch, Principal Investigator, Holdsworth House Medical Practice
History of Changes
|Other Study ID Numbers:
|Study First Received:
||June 30, 2010
||September 8, 2013
||Australia: Human Research Ethics Committee
Keywords provided by Holdsworth House Medical Practice:
Antiretroviral therapy experienced
failed NNRTI regime
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 26, 2015
Reverse Transcriptase Inhibitors
Molecular Mechanisms of Pharmacological Action
Nucleic Acid Synthesis Inhibitors