Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
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|ClinicalTrials.gov Identifier: NCT01149889|
Recruitment Status : Completed
First Posted : June 24, 2010
Last Update Posted : December 6, 2011
|Condition or disease||Intervention/treatment||Phase|
|Major Depressive Disorder||Procedure: transcranial direct current stimulation||Phase 2 Phase 3|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||60 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||An Open-label, Crossover Study on Major Depressive Disorder Using Transcranial Direct Current Stimulation|
|Study Start Date :||June 2010|
|Actual Primary Completion Date :||September 2011|
|Actual Study Completion Date :||December 2011|
Experimental: active stimulation
In active stimulation, the anode is placed over the left dorsolateral prefrontal cortex and the cathode is placed over the right prefrontal cortex. They are located five centimeters ventrally of the primary motor area, which are located five centimeters laterally of the central point of the scalp (which is located on the intersection of the sagittal and median curves). The device will deliver a charge of 2mA for 30 minutes.
Procedure: transcranial direct current stimulation
Transcranial direct current stimulation will be applied at 2mA, 30 minutes/day, for 10 weekdays consecutively
- Treatment Response [ Time Frame: Week 1 ]Response is defined as MADRS <=12 or less than 50% of baseline MADRS (Montgomery Asberg depression rating score).
- Treatment response [ Time Frame: Week 2 ]Response defined as above.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01149889
|University of Sao Paulo|
|Sao Paulo, SP, Brazil|
|Principal Investigator:||Andre R Brunoni, MD||University of Sao Paulo|