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Immunological Change and the Single Nucleotide Polymorphism (SNP) in Children With Irritable Bowel Syndrome (IBS)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2010 by Chang Gung Memorial Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01131442
First Posted: May 27, 2010
Last Update Posted: May 27, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Chang Gung Memorial Hospital
  Purpose
Currently, the pathophysiology of Irritable bowel syndrome( IBS) remains unclear . The purpose of this study is want to investigate the immunological changes in the children with IBS.

Condition
Irritable Bowel Syndrome Children

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional

Further study details as provided by Chang Gung Memorial Hospital:

Estimated Enrollment: 40
Study Start Date: November 2008
Groups/Cohorts
The patient group
healthy control group

Detailed Description:
Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder.Many children suffered from this disease and had impact on their daily life. However, the underlying pathophysiologic mechanisms remain to be elucidate. Dysregulation of the gut immune system is considered an important pathophysiology. We want to investigate the immunological changes in the IBS children.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   5 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
out patient clinics in the hospital
Criteria

Inclusion Criteria:

  • (5-18y/o) with IBS,
  • All patients had chronic or relapsing symptoms of IBS consistent with the ROME II criteria

Exclusion Criteria:

  • A history of psychologic disorders, probiotics, anti-inflammatory, analgesic, or immunosuppressive medication (nonsteroidal anti-inflammatory drugs, steroids) within the past 3 months were excluded
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01131442


Locations
Taiwan
Chang Gung Memeorial Hospital Recruiting
Keelung, Taiwan
Contact: Man-Chin Hua, M.D.    886-2-24313131 ext 2626    menchinhua@gmail.com   
Principal Investigator: Man-Chin Hua Hua, M.D.         
Sponsors and Collaborators
Chang Gung Memorial Hospital
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier: NCT01131442     History of Changes
Other Study ID Numbers: CMRPG270371
First Submitted: May 25, 2010
First Posted: May 27, 2010
Last Update Posted: May 27, 2010
Last Verified: May 2010

Keywords provided by Chang Gung Memorial Hospital:
immune

Additional relevant MeSH terms:
Syndrome
Irritable Bowel Syndrome
Disease
Pathologic Processes
Colonic Diseases, Functional
Colonic Diseases
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases