Assessment of the Prescriber's and the Pharmacies Overview of Patient Medication by Use of the Fidelity Coefficient.
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|ClinicalTrials.gov Identifier: NCT01128660|
Recruitment Status : Completed
First Posted : May 24, 2010
Last Update Posted : February 4, 2013
|Condition or disease|
|Misuse of Prescription Only Drugs|
The fidelity coefficient, FC, is a measure of what proportion of individual patients' medication that are accounted for by the most used prescriber and the most used pharmacy. Each patient therefore has two values, one describing his fidelity towards his most used prescriber, FCPresc, and one describing his fidelity towards his most used pharmacy, FCPharm.
The investigators intend to assess this parameter in an observational population scale database study, using standard descriptive statistics, and subsequently compare the obtained average FCPresc and FCPharm.
Furthermore, the investigators will analyze the two obtained FCs for dependency of a predefined list of variables: age, gender, number of prescriptions, whether the most frequent prescriber was a GP and whether the most used pharmacy was urban.
Finally, the investigators intend to analyze which medications (grouped using the ATC-system with 4 digits, e.g. C07A) that has the highest proportion of prescriptions that were either issued by a non-main prescriber or redeemed at a non-main pharmacy, which roughly translates into the most 'infidel' medications. To insure relevance we intend to use a cut-off-value of the medication being prescribed at least 50.000 times, which equals about 85 % of the data according to preceding analyses.
The data for this study will be obtained from the Odense University Pharmacoepidemiological Database (OPED). In brief, it is a research database with full coverage of all reimbursed prescriptions in the Region of Southern Denmark (1.2 million inhabitants). The data included in each prescription record includes the prescription holder, the prescriber, the pharmacy, the date of dispensing and a full account of the dispensed product, including substance, brand name, route of administration, ATC-code and Defined Daily Dose (DDD).
Some drugs are exempt from re-imbursement and thus not covered by the database, including benzodiazepines, oral contraceptives, laxatives and certain antibiotics.
|Study Type :||Observational|
|Actual Enrollment :||283388 participants|
|Official Title:||Assessment of the Prescriber's and the Pharmacies Overview of Patient Medication by Use of the Fidelity Coefficient.|
|Study Start Date :||June 2010|
|Actual Primary Completion Date :||June 2010|
|Actual Study Completion Date :||August 2010|
Residents of Southern Denmark, who filed more than 9 prescriptions during 2009.
- FC(Pharm) [ Time Frame: cross-sectional study with data aquisition over one year ]The pharmacy fidelity coefficient, FC(Pharm), is a measure of what proportion of individual patients' medication that are accounted for by the most used pharmacy.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01128660
|Research Unit of Clinical Pharmacology, University of Southern Denmark|
|Odense, Funen, Denmark, 5000|
|Principal Investigator:||Jesper Hallas, MD, PhD||Professor, Research Unit of Clinical Pharmacology, University of Southern Denmark.|
|Principal Investigator:||Anton Pottegard, BSc in Pharm||Guest Researcher, Research Unit of Clinical Pharmacology, University of Southern Denmark.|