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The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

This study has been completed.
Information provided by:
University of Cologne Identifier:
First received: May 3, 2010
Last updated: April 12, 2013
Last verified: April 2013
The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.

Condition Intervention
Wound Healing
Procedure: Trabeculectomy

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

Resource links provided by NLM:

Further study details as provided by University of Cologne:

Study Start Date: October 2009
Study Completion Date: March 2012
Primary Completion Date: January 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Glaucoma patients Procedure: Trabeculectomy
Trabeculectomy with mitomycin C


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients from the University Eye Hospital of Cologne

Inclusion Criteria:

  • patients with glaucoma with a trabeculectomy required
  • 60 eyes of 60 patients, The ratio of female / male is not involved.
  • Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table).
  • age of at least 18 years

Exclusion Criteria:

  • all patients not included in the group of inclusion criteria.
  • less than 50yl anterior chamber fluid could be collected during the operation.
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Please refer to this study by its identifier: NCT01115218

University Eye Hospital, University of Cologne
Cologne, NRW, Germany, 50937
Sponsors and Collaborators
University of Cologne
  More Information

Responsible Party: Arno Hueber, MD, University of Cologne Identifier: NCT01115218     History of Changes
Other Study ID Numbers: MeVeTra-2009
Study First Received: May 3, 2010
Last Updated: April 12, 2013

Keywords provided by University of Cologne:

Additional relevant MeSH terms:
Ocular Hypertension
Eye Diseases processed this record on May 25, 2017