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Comparison of 1 vs 3 Sets of Resistance Training on Muscular Hypertrophy

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ClinicalTrials.gov Identifier: NCT01107691
Recruitment Status : Completed
First Posted : April 21, 2010
Last Update Posted : May 29, 2015
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
Richard Washburn, University of Kansas

Brief Summary:

This study is designed to investigate the effects of two levels of resistance weight training on body composition, energy expenditure, and energy intake in men and women. The weight training will take about one hour to complete. Participants will perform the training 3 days per week for 9 months in a private exercise room equipped with state of the art equipment and a personal trainer to help guide you through the exercises.

The project lasts 21 months total with one follow-up visit 1-year from your last training date. You will be required to stay in the Lawrence area and train 3 day/week over the summer & holidays.


Condition or disease Intervention/treatment Phase
Obesity Other: Amount of resistance offered in training Not Applicable

Detailed Description:
We propose to conduct a randomized controlled efficacy trial (RT-1 set vs. RT-3 sets vs. non exercise control) to evaluate the potential for a longer intervention (9 months RT with body composition assessments 1 yr post RT completion) with a higher volume of RT (3 sets) to enhance the effects on body composition and energy expenditure observed in the pilot, and to determine the impact of the 2 levels of RT on free-living energy balance (expenditure by doubly labeled water and intake by digital photography and 24-hr recalls). This investigation will be conducted in a sample of healthy, normal and overweight, sedentary, young adult men and women; a group at high risk for development of overweight and obesity. The specific aims of this project are to determine the impact of the volume (1 vs. 3 sets) of a progressive RT protocol for inducing muscular hypertrophy, as recommended by the American College of Sports Medicine, on body weight and body composition (fat mass, fat-free mass (FFM), % body fat) and energy balance. Our results will provide information relative to the minimum volume of RT that may be associated with body weight/fat gain which may inform the development of guidelines for RT to prevent weight gain or to alter body composition. If RT has a favorable impact on energy balance and body composition, it may provide an attractive alternative to aerobic exercise for weight management for busy young adults, as RT requires minimal time, and no need to change clothes or shower (i.e. minimal or no sweating).

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 169 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Resistance Training Energy Balance & Weight Management
Study Start Date : April 2009
Actual Primary Completion Date : March 2014
Actual Study Completion Date : March 2014

Arm Intervention/treatment
Experimental: Resistance training
1 set of progressive resistance training per session
Other: Amount of resistance offered in training
to determine the impact of the volume (1 vs. 3 sets) of a progressive resistance training protocol for inducing muscular hypertrophy

Experimental: 3 sets per session
3 sets of progressive resistance training per session
Other: Amount of resistance offered in training
to determine the impact of the volume (1 vs. 3 sets) of a progressive resistance training protocol for inducing muscular hypertrophy

No Intervention: Control
Non exercise control group



Primary Outcome Measures :
  1. Body Composition [ Time Frame: 21 Months ]
    Changes in body composition will be evaluated by measuring the change in percent body fat, total fat mass, and total lean mass by dual energy x-ray absorptiometry (DEXA).


Secondary Outcome Measures :
  1. Resting Metabolic Rate [ Time Frame: 9 months ]
    Resting metabolic rate as measured by indirect calorimetry as kcal/day will be evaluated. Also, substrate oxidation (fat and carbohydrate oxidation) will be evaluated at these time points.

  2. Muscular Strength [ Time Frame: 9 months ]
    One rep max strength will be measured on the chest and leg press.

  3. Daily Energy Expenditure [ Time Frame: 9 months ]
    Total daily energy expenditure over a 14 day period will be measured using doubly labeled water.



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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI 22-<30
  • 18- 30 years old
  • sedentary
  • no medications
  • weight stable for at least 3 months

Exclusion Criteria:

  • Tobacco/Drug user
  • metabolism altering medication
  • gain/lost 10lbs in the last 3 months
  • current exerciser

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01107691


Locations
United States, Kansas
Energy Balance Lab, The University of Kansas
Lawrence, Kansas, United States, 66045
Sponsors and Collaborators
University of Kansas
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Principal Investigator: Richard A Washburn, PhD University of Kansas

Responsible Party: Richard Washburn, Associate Professor, University of Kansas
ClinicalTrials.gov Identifier: NCT01107691     History of Changes
Other Study ID Numbers: HSCL17623
NIDDKRO180832 ( Other Grant/Funding Number: National Institues of Health )
First Posted: April 21, 2010    Key Record Dates
Last Update Posted: May 29, 2015
Last Verified: May 2015

Keywords provided by Richard Washburn, University of Kansas:
resistance and weight loss training