We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

Prevention of Stroke and Dementia in Primary Care (INVADE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01107548
Recruitment Status : Terminated
First Posted : April 21, 2010
Last Update Posted : February 20, 2012
Information provided by:

Study Description
Brief Summary:

In Western Countries, stroke and dementia are the main causes of long-term disability, dependency, and nursing home admission. Due to demographic trends a continuous increase of patient numbers can be expected.

There is growing evidence that vascular risk factors which are implicated in the etiology of stroke also play important etiologic roles in both vascular dementia and Alzheimer disease. The present project is aimed at the reduction of stroke and dementia by means of a systematic detection and subsequent treatment of vascular risk factors by the family doctor based on established guidelines.

Condition or disease Intervention/treatment
Stroke Dementia Disability Other: Systematic detection of vascular risk factors and subsequent evidence-based treatment

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 3908 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Intervention Project of Cerebrovascular Diseases and Dementia in the District of Ebersberg
Study Start Date : January 2001
Primary Completion Date : December 2008
Study Completion Date : March 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dementia
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: Evidence-based treatment, lifestyle counseling Other: Systematic detection of vascular risk factors and subsequent evidence-based treatment

Outcome Measures

Primary Outcome Measures :
  1. Incidence of long-term care disability [ Time Frame: 8 years ]
  2. Incidence of stroke [ Time Frame: 8 Years ]

Secondary Outcome Measures :
  1. Reduction of cardiovascular risk factors [ Time Frame: 8 years ]

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   55 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Age 55 years or over
  • Member of a particular health insurance plan (AOK)
  • Resident of the district of Ebersberg

Exclusion Criteria:

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01107548

Depts. of Psychiatry and Neurology, Technische Universität München
Munich, Germany, D-81675
Sponsors and Collaborators
Technische Universität München
Allgemeine Ortskrankenkasse Bayern (AOK)
Stiftung Deutsche Schlaganfall-Hilfe
Ratiopharm GmbH
Teva Pharma GmbH
Berlin-Chemie Menarini
Principal Investigator: Horst Bickel, PhD Dept. of Psychiatry, Technical University of Munich
More Information

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Horst Bickel, Dept. of Psychiatry, Technical University of munich
ClinicalTrials.gov Identifier: NCT01107548     History of Changes
Other Study ID Numbers: 080250hb
First Posted: April 21, 2010    Key Record Dates
Last Update Posted: February 20, 2012
Last Verified: April 2010

Additional relevant MeSH terms:
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Neurocognitive Disorders
Mental Disorders