Low Grade Inflammation in Type 1 Diabetes Children (Coccinelle)
The study propose to measure the inflammation level in type 1 diabetes children with the cytokine analysis compared to non diabetic children of the same sibling and to healthy children.
Type 1 Diabetes
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Low Grade Inflammation in Type 1 Diabetes Children|
- Increase of Interleukine 6 in group DTI versus control group [ Time Frame: Once at inclusion ] [ Designated as safety issue: No ]
- Increase of others cytokines (IL1-beta, l'IL-4, l'IL-10 and TNF alpha) and increase of High sensitivity CRP in group DTI versus control group [ Time Frame: Once at inclusion ] [ Designated as safety issue: No ]
|Study Start Date:||April 2010|
|Study Completion Date:||July 2010|
|Primary Completion Date:||July 2010 (Final data collection date for primary outcome measure)|
The increase of type 1 diabetes incidence, particularly in young children leads to conduce new diagnostic and therapeutic strategies, notably for associated chronic morbidity.Measurement of chronic inflammation, with modification of the balance between pro-inflammatory cytokines and anti-inflammatory cytokines, could lead to detect patients with high risk to diabetes chronic morbidity.
After parental consent, blood sampling will be carried out by micromethod for cytokine (500 µl) and CRPhs dosages and glycemia (100 µl) and glycated hemoglobin (1 µl). Urine will be collected (50 ml) in the morning for further researches.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01099956
|Children Hospital, Endocrinology Unit|
|Bordeaux, France, 33076|
|Principal Investigator:||Pascal BARAT, MD||University Hospital, Bordeaux, France|