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Effects of Marijuana Used on Lung Function in Persons With Chronic Obstructive Pulmonary Disease (COPD)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Rosa Estrada Y Martin, The University of Texas Health Science Center, Houston
ClinicalTrials.gov Identifier:
NCT01096303
First received: March 24, 2010
Last updated: May 12, 2017
Last verified: May 2017
  Purpose
The main hypothesis is that persons that smoke or smoked tobacco and marihuana have worsen lung function as compared with persons that only smoke or smoked tobacco.

Condition
Chronic Obstructive Pulmonary Disease

Study Type: Observational
Study Design: Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Effects of Marijuana Smoking on Pulmonary Function in Patients With COPD

Resource links provided by NLM:


Further study details as provided by Rosa Estrada Y Martin, The University of Texas Health Science Center, Houston:

Primary Outcome Measures:
  • Obstructive limitation in pulmonary function test [ Time Frame: 1 year ]
    Comparison on the severity of obstruction among both groups


Secondary Outcome Measures:
  • Decreased diffusion capacity for carbon monoxide [ Time Frame: 1 year ]
    Comparison on the severity of decreased DLco among groups.

  • Airtrapping [ Time Frame: 1 year ]
    Comparison on the severity of air-trapping by pulmonary function testing among groups.


Enrollment: 200
Study Start Date: November 2010
Study Completion Date: December 31, 2016
Primary Completion Date: December 31, 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts
COPD tobacco and/or marihuana users
COPD patients with history of tobacco and/or marihuana smoking.

Detailed Description:
We will follow persons with already diagnosed COPD (chronic bronchitis and/or emphysema). Obtain their smoking history: tobacco and marihuana and review their pulmonary function study results. Then we are planning to compare both groups.
  Eligibility

Ages Eligible for Study:   25 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
COPD patients recruited in pulmonary clinic.
Criteria

Inclusion Criteria:

  • COPD patients former or current tobacco smokers
  • COPD patients former or current tobacco and marihuana smokers

Exclusion Criteria:

  • History of COPD without pulmonary function testing
  • Refusal to provide smoking or marihuana used history
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01096303

Locations
United States, Texas
Lyndon B Johnson General Hospital
Houston, Texas, United States, 77026
The University of Texas- Health Science Center at Houston
Houston, Texas, United States, 77030
Sponsors and Collaborators
The University of Texas Health Science Center, Houston
Investigators
Principal Investigator: Rosa M Estrada-Y-Martin, MD The University of Texas Health Science Center, Houston
  More Information

Responsible Party: Rosa Estrada Y Martin, Associate Professor - I/M Pulmonary and Critical Care, The University of Texas Health Science Center, Houston
ClinicalTrials.gov Identifier: NCT01096303     History of Changes
Other Study ID Numbers: HSC-MS-09-0362
Study First Received: March 24, 2010
Last Updated: May 12, 2017

Keywords provided by Rosa Estrada Y Martin, The University of Texas Health Science Center, Houston:
COPD
pulmonary function
tobacco and marihuana smoking

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Marijuana Abuse
Respiratory Tract Diseases
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders

ClinicalTrials.gov processed this record on July 26, 2017