Genetics of Obesity in Chinese Youngs (GOCY)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01084967|
Recruitment Status : Recruiting
First Posted : March 11, 2010
Last Update Posted : April 26, 2016
|Condition or disease|
|Obesity Metabolic Syndrome|
Obesity has become a major worldwide challenge to public health, owing to an interaction between the obesogenic environment and a strong genetic contribution.Previous studies found that genetic factors determine 40%-70% of obese phenotype.Under such circumstances, the screening of obesity susceptibility gene is particularly important for society or family to take measures to prevent obesity.
Recent extensive genome-wide association studies(GWASs) have identified numerous single nucleotide polymorphisms associated with obesity,but these loci together account for only a small fraction of the known heritable component.Two studies in 2010 Nature,for the first time, put rare copy number variation (CNV)in association with severe early-onset obesity.Their significance lie not only in the discovery of the pathogenic genes of severe early-onset obesity but,more importantly,in providing new strategies for finding out genes that cause complex diseases.
Obese patients and healthy lean controls proved by a series of blood biochemical examinations will be enrolled in this study.The present study intends to use the techniques such as enzyme-linked immunosorbent assay, real-time fluorescence quantitative PCR,gene chip,construction of viral vectors,transfection,taking advantage of the established database,by means of serum assays and functional tests, associate copy number variation with obesity phenotype to explain the root cause of obesity.Meanwhile biomarkers and genetic risk factors will be evaluated in the study subjects.
|Study Type :||Observational|
|Estimated Enrollment :||3000 participants|
|Official Title:||Study of Clinical Characteristics and Genetic Susceptibility in Chinese Obese Youngs|
|Study Start Date :||March 2009|
|Estimated Primary Completion Date :||April 2021|
|Estimated Study Completion Date :||April 2021|
Healthy lean control group
BMI:18.5-22.9kg/m2. Age:14-30 years old. To be proved normal by the examinations of liver and kidney function,blood lipids profile,fasting and postprandial plasma glucose, fasting insulin and HbA1c.
obesity group with BMI ≥30
obesity group 1500, lean healthy control group 1500
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01084967
|Contact: Guang Ning, MD.PhD||86-21-64370045 ext email@example.com|
|Contact: Jie Hong, PhD||86-21-64370045 ext firstname.lastname@example.org|
|Shanghai Jiao Tong University School of Medicine||Recruiting|
|Shanghai, Shanghai, China, 200025|
|Contact: Guang Ning, MD.PhD 86-21-64370045 ext 665340 email@example.com|
|Contact: Jie Hong, PhD 86-21-64370045 ext 665345 firstname.lastname@example.org|
|Principal Investigator: Guang Ning, MD.PhD|
|Principal Investigator:||Guang Ning, MD.PhD||Shanghai Jiao Tong University School of Medicine|