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Stiffness of the Skin and Joints in Relation to Carpal Tunnel Syndrome (STIF-CTS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01081860
Recruitment Status : Unknown
Verified April 2010 by St. Antonius Hospital.
Recruitment status was:  Not yet recruiting
First Posted : March 5, 2010
Last Update Posted : April 27, 2010
Information provided by:
St. Antonius Hospital

Brief Summary:

The exact etiology of CTS remains yet unknown. A rise in carpal tunnel pressure is well documented, but why this phenomenon occurs is yet unknown in most patients. There is an absolute or relative narrowing of the carpal tunnel, which results in a compression of the median nerve.

The investigators postulate, that a stiffer flexor retinaculum (roof of carpal tunnel) will be less compliant. As a consequence of this stiffer retinaculum the pressure in the carpal tunnel will rise more quickly in stiff patients resulting in CTS-complaints.

A relation between connective tissue composition and joint stiffness is proven. This relationship possibly extends to a relation between stiffness of the skin, joint stiffness and the prevalence of CTS.

Condition or disease
Carpal Tunnel Syndrome

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Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Correlation of Joint Stiffness and Stiffness of the Skin and the Prevelation of Carpal Tunnel Syndrome (CTS)
Study Start Date : May 2010
Estimated Primary Completion Date : November 2010
Estimated Study Completion Date : December 2010

Carpal tunnel syndrome
Patients with carpal tunnel syndrome
Trigger finger
Patients with trigger fingers
Dupuytren Contracture
Patients with Dupuytren
Trauma to the hand
Patients with an acute trauma to the hand

Primary Outcome Measures :
  1. Joint stiffness [ Time Frame: In the 1st month ]
    The active range of motion (elbow, wrist, knee and ankle) is measured with a standard goniometer.

  2. Stiffness of the skin [ Time Frame: in the 1st month ]
    Skinstiffness is measured with a suction cup

Secondary Outcome Measures :
  1. Physical activities [ Time Frame: In the 1st month ]
    Boston Questionairre

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Patients presenting with complaints of:

  • Carpal tunnel syndrome
  • Trigger finger
  • Dupuytren contracture
  • an acute trauma to the hand

Inclusion Criteria:

  • Caucasian
  • Carpal tunnel release OR Trigger finger OR Dupuytren OR an acute trauma to the hand

Exclusion Criteria:

  • Hypo-/hyperthyroidism
  • Diabetes
  • Arthritis
  • Pregnancy
  • Obesity (BMI >30)
  • Anatomical anomalies

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01081860

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Contact: Bo Verwer

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St Antonius Hospital
Nieuwegein, Utrecht, Netherlands, 3430EM
Contact: Bo Verwer   
Sponsors and Collaborators
St. Antonius Hospital
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Principal Investigator: A.B. Mink van der Molen, dr. St. Antonius Hospital
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Responsible Party: dr. A.B. Mink van der Molen, department of plastic surgery St Antonius Hospital Identifier: NCT01081860    
Other Study ID Numbers: STIF CTS
First Posted: March 5, 2010    Key Record Dates
Last Update Posted: April 27, 2010
Last Verified: April 2010
Keywords provided by St. Antonius Hospital:
Carpal tunnel syndrome
Additional relevant MeSH terms:
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Carpal Tunnel Syndrome
Pathologic Processes
Median Neuropathy
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nervous System Diseases
Nerve Compression Syndromes
Cumulative Trauma Disorders
Sprains and Strains
Wounds and Injuries