Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial
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|ClinicalTrials.gov Identifier: NCT01076881|
Recruitment Status : Completed
First Posted : February 26, 2010
Last Update Posted : February 26, 2010
This is a randomized trial with participants recruited from one dialysis unit of a Brazilian university hospital. Hemodialysis patients were assigned to receive the resistance exercise combined with an aerobic training or the resistance training alone for a period of 10 weeks. The functional performance of patients was assessed before and after the intervention through the six-minute walk test (6MWT). The difference over time of the 6MWT was compared between the groups through multivariate linear regression.
Thirteen patients were allocated for each group of intervention. The difference in distance walked before and after intervention in the combined training group was of +39.7 (61.4) meters, and this difference in the resistance training group was of -19.2 (53.9) meters, p=0.01. In multivariate analysis with adjustment for age, skin color, gender, hematocrit, time since starting dialysis, Kt/V and baseline values of 6MWT, the type of training remained significantly associated with the amount of increase in walked distance.
Although the best protocol of exercise for patients on dialysis is not yet clear, in the investigators sample of hemodialysis patients the combination of aerobic and resistance training was more effective to improve functional performance.
|Condition or disease||Intervention/treatment||Phase|
|End Stage Renal Disease||Behavioral: exercise training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||26 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Primary Purpose:||Supportive Care|
|Official Title:||Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial|
|Study Start Date :||December 2008|
|Actual Primary Completion Date :||March 2009|
|Actual Study Completion Date :||March 2009|
|Experimental: combined aerobic and resistance training||
Behavioral: exercise training
|Active Comparator: resistance training alone||
Behavioral: exercise training
- physical performance [ Time Frame: 10 weeks ]
- dialysis adequacy (KtV) [ Time Frame: 4/8/10 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01076881
|Hospital Universitário São Francisco de Paula|
|Pelotas, RS, Brazil|