Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial

This study has been completed.
Information provided by:
Universidade Católica de Pelotas Identifier:
First received: February 17, 2010
Last updated: February 25, 2010
Last verified: February 2010

This is a randomized trial with participants recruited from one dialysis unit of a Brazilian university hospital. Hemodialysis patients were assigned to receive the resistance exercise combined with an aerobic training or the resistance training alone for a period of 10 weeks. The functional performance of patients was assessed before and after the intervention through the six-minute walk test (6MWT). The difference over time of the 6MWT was compared between the groups through multivariate linear regression.

Thirteen patients were allocated for each group of intervention. The difference in distance walked before and after intervention in the combined training group was of +39.7 (61.4) meters, and this difference in the resistance training group was of -19.2 (53.9) meters, p=0.01. In multivariate analysis with adjustment for age, skin color, gender, hematocrit, time since starting dialysis, Kt/V and baseline values of 6MWT, the type of training remained significantly associated with the amount of increase in walked distance.

Although the best protocol of exercise for patients on dialysis is not yet clear, in the investigators sample of hemodialysis patients the combination of aerobic and resistance training was more effective to improve functional performance.

Condition Intervention
End Stage Renal Disease
Behavioral: exercise training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial

Resource links provided by NLM:

Further study details as provided by Universidade Católica de Pelotas:

Primary Outcome Measures:
  • physical performance [ Time Frame: 10 weeks ]

Secondary Outcome Measures:
  • dialysis adequacy (KtV) [ Time Frame: 4/8/10 weeks ]

Enrollment: 26
Study Start Date: December 2008
Study Completion Date: March 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: combined aerobic and resistance training Behavioral: exercise training
Active Comparator: resistance training alone Behavioral: exercise training


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • to be on hemodialysis therapy for longer than 3 months
  • to be already included in the resistance training protocol during dialysis
  • to receive erythropoietin for the treatment of anemia
  • hemoglobin level greater than 9.0 g/dL
  • to be able to maintain sitting and standing balance and ambulatory without assistance.

Exclusion Criteria:

  • symptomatic ischemic heart disease
  • recent myocardial infarction of less than 6 months
  • uncontrolled hypertension
  • pericardial or pleural friction rub
  • aortic stenosis
  • active musculoskeletal lower-extremity problem, or history of vertebral fracture caused by osteoporosis
  • patients were also excluded if they participated in formal organized exercise programs outside the dialysis unit.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01076881

Hospital Universitário São Francisco de Paula
Pelotas, RS, Brazil
Sponsors and Collaborators
Universidade Católica de Pelotas
  More Information Identifier: NCT01076881     History of Changes
Other Study ID Numbers: UCPelotas01
Study First Received: February 17, 2010
Last Updated: February 25, 2010

Additional relevant MeSH terms:
Kidney Failure, Chronic
Renal Insufficiency, Chronic
Renal Insufficiency
Kidney Diseases
Urologic Diseases processed this record on May 23, 2017