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Functional Neuroimaging of Cortical Plasticity in the Human Visual System

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01062672
Recruitment Status : Withdrawn (PI left institution and no participants were enrolled)
First Posted : February 4, 2010
Last Update Posted : April 11, 2022
Brigham and Women's Hospital
Information provided by (Responsible Party):
Eli M Mizrahi, Baylor College of Medicine

Brief Summary:
The study's objective is to measure changes in human visual cortex organization that may arise as a result of injury to the visual pathways. Subjects with retinal or cortical injury will be studied and compared to appropriate controls. Functional magnetic resonance imaging methods are used to monitor cortical topography in time. The main aims of the study are to determine: 1) what are the patterns of cortical reorganization that are seen spontaneously after injury, and 2) whether rehabilitative training can promote adaptive reorganization enhancing recovery.

Condition or disease
Stroke Blindness Vision

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Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Functional Neuroimaging of Cortical Plasticity in the Human Visual System
Actual Study Start Date : January 2009
Actual Primary Completion Date : December 2015
Actual Study Completion Date : December 2015

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with lesions of the visual pathway (cortical or retinal)

Inclusion Criteria:

  • Stable lesion of the visual pathways resulting in a visual field scotoma.

Exclusion Criteria:

  • Inability to undergo magnetic resonance imaging,
  • Inability to comply with basic instructions,
  • Inability to perform the behavioral tasks required,
  • Patients with chronic progressive neurological or psychiatric disorders,
  • Patients that are pregnant, or breast feeding.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01062672

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United States, Texas
Baylor College of Medicine
Houston, Texas, United States, 77030
Max Planck Institute for Biological Cybernetics
Tuebingen, Germany
Sponsors and Collaborators
Baylor College of Medicine
Brigham and Women's Hospital
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Responsible Party: Eli M Mizrahi, Professor, Baylor College of Medicine Identifier: NCT01062672    
Other Study ID Numbers: H--22516
First Posted: February 4, 2010    Key Record Dates
Last Update Posted: April 11, 2022
Last Verified: April 2022
Keywords provided by Eli M Mizrahi, Baylor College of Medicine:
Additional relevant MeSH terms:
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Vision Disorders
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Eye Diseases