Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs)
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|ClinicalTrials.gov Identifier: NCT01062035|
Recruitment Status : Completed
First Posted : February 4, 2010
Last Update Posted : June 26, 2014
|Condition or disease|
Telomeres are the repetitive DNA sequences that cap both ends of chromosomes. Shortening of peripheral blood lymphocyte (PBL) telomeres has been associated with renal and other cancers. The investigators' preliminary data shows an association between shorter PBL telomere length and ACPs.
I. Specific Aims
- Develop a DNA and data repository from individuals with advanced colon polyps (ACPs) and controls
- Confirm that individuals 50 to 60 years of age with ACPs tend to have shorter peripheral blood lymphocyte (PBL) telomeres than those without ACPs
- Identify a potential optimal PBL telomere length cut-off to differentiate between individuals with ACPs and those without for evaluation in a larger scale study
The over reaching long term goal is to decrease disease and death from colorectal cancer (CRC) using a biomarker strategy to target colonoscopy to those at higher risk.
|Study Type :||Observational|
|Actual Enrollment :||72 participants|
|Observational Model:||Case Control|
|Official Title:||Peripheral Blood Telomere Length as a Biomarker of Advanced Colorectal Adenomas|
|Study Start Date :||January 2010|
|Actual Primary Completion Date :||September 2013|
|Actual Study Completion Date :||September 2013|
ACP (advanced colon polyp) Group
Between the ages of 50 and 60 years old and have an ACP (advanced colon polyp)
Individuals between the ages of 50 and 60 years old who have had a negative screening colonoscopy.
- Telomere length are shorter in individuals with colon polyps. [ Time Frame: 2 years ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01062035
|United States, Florida|
|Mayo Clinic Jacksonville|
|Jacksonville, Florida, United States, 32224|
|Principal Investigator:||Douglas L Riegert-Johnson, M.D.||Mayo Clinic|