Chemoreflex Gain on Exercise
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|ClinicalTrials.gov Identifier: NCT01050179|
Recruitment Status : Unknown
Verified April 2010 by Imperial College London.
Recruitment status was: Recruiting
First Posted : January 15, 2010
Last Update Posted : April 19, 2010
|Condition or disease||Intervention/treatment||Phase|
|Exertional Periodic Breathing||Other: carbon dioxide||Phase 1|
Normally breathing is controlled by a reflex that responds to the levels of carbon dioxide (CO2) in the blood. The change in breathing that results from a change in the blood's CO2 concentration is called the chemoreflex.
In heart failure, a condition where the heart muscle is damaged and can not pump as well, this reflex is exaggerated. The result of this can be breathing conditions characterised by patients hyperventilating at times and at other times taking very shallow breaths or even stopping altogether. In the past the only way of measuring this chemoreflex was to get patients to breathe into a large container and to rebreathe their exhaled air and allow the CO2 to rise over time, whilst keeping the oxygen constant. The proportion by which the ventilation increases with increasing carbon dioxide is the chemoreflex gain. Unfortunately, because this test takes a long time to conduct, requires specialist knowledge and equipment it has not been possible to measure this reflex on exercise.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Chemoreflex Gain on Exercise|
|Study Start Date :||February 2010|
|Estimated Primary Completion Date :||October 2010|
|Estimated Study Completion Date :||October 2010|
- Other: carbon dioxide
sinusoidal carbon dioxide delivery
- chemoreflex gain on exercise [ Time Frame: every minute ]
- Reproducibility of chemoreflex gain on exercise [ Time Frame: every minute ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01050179
|Contact: Darrel P Francis, MD||+44 207 594 firstname.lastname@example.org|
|St Mary's Hospital||Recruiting|
|Paddington, London, United Kingdom, W2 1LA|
|Contact: Resham Baruah, MBBS 02075941027 email@example.com|
|Principal Investigator: Darrel P Francis, MD|