The Hemodynamic Response to Prolonged Dobutamine Infusion
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|ClinicalTrials.gov Identifier: NCT01042873|
Recruitment Status : Recruiting
First Posted : January 6, 2010
Last Update Posted : July 6, 2011
A decrease in the response of beta 1 adrenergic receptors to agonists (desensitization) is thought to play a major role in the pathogenesis of diseases such as congestive heart failure. However, currently, there is no in vivo model that will enable us to measure desensitization of the hemodynamic responses to beta 1 adrenergic receptors in vivo.
Our hypothesis is that constant 3 hours intravenous infusion of the selective beta1 adrenergic receptor agonist dobutamine will result in gradual decline in hemodynamic responses to dobutamine over time.
|Condition or disease||Intervention/treatment||Phase|
|Healthy Heart Failure||Drug: 3 hours intravenous dobutamine||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||100 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||January 2010|
|Estimated Primary Completion Date :||December 2015|
|Estimated Study Completion Date :||December 2019|
3 hours infusion of dobutamine
Drug: 3 hours intravenous dobutamine
Intravenous dobutamine will be infused during 3 hours. At the first and last 0.5 hors of infusion dose will be increased gradually, while in the middle 2 hours dose will remain constant.
- Heart rate [ Time Frame: 3 hours ]
- Systolic blood pressure [ Time Frame: 3 hours ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01042873
|Hadassah University Hospital||Recruiting|
|Jerusalem, Israel, 91120|
|Contact: Mordechai Muszkat, MD 972-2-6777335 firstname.lastname@example.org|
|Principal Investigator: Mordechai Muszkat, MD|