Agouti-related Peptide (AgRP) in Healthy Mothers and Mothers With Preeclampsia and Their Offspring
|ClinicalTrials.gov Identifier: NCT01042210|
Recruitment Status : Completed
First Posted : January 5, 2010
Last Update Posted : January 5, 2010
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||84 participants|
|Observational Model:||Case Control|
|Official Title:||Genotype-phenotype Associations of Agouti-related Peptide (AgRP) in Postpartum Period in Preeclamptic and Non-preeclamptic Women and Their Offspring|
|Study Start Date :||January 2005|
|Actual Primary Completion Date :||March 2006|
|Actual Study Completion Date :||December 2006|
Mothers with preeclampsia diagnosed according to the Guidelines by the Czech Society of obstetrics and gynecology as development of hypertension after the 20th week of pregnancy (systolic blood pressure, ≥140 mmHg; and/or diastolic blood pressure, ≥90 mmHg; measured at rest on two consecutive occasions at least 24 h apart) in previously normotensive women, and the onset of proteinuria (>300 mg of urinary protein/L over 24 h).
Newborns, physiological pregnancy-delivery
The newborns from the physiological pregnancies with spontaneous, uncomplicated delivery.
Newborns, pregnancy with preeclampsia
Newborns from the pregnancies complicated by preeclampsia.
Mothers, Physiological pregnancy-labour
The cohort of non-preeclamptic mothers with physiological, uncomplicated conception, pregnancy and delivery.
- plasma/serum level of agouti/related peptide in peripheral blood in postpartum mother [ Time Frame: 2-4 hours postpartum ]
- Plasma level of agouti-related peptide in umbilical cord blood from the newborn [ Time Frame: immediately postpartum ]
- maternal weight gain during pregnancy [ Time Frame: using postpartum and peripartum data ]
- birth weight of the newborn [ Time Frame: immediately postpartum ]
- maternal preconceptional BMI [ Time Frame: anamnestic information ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01042210
|Masaryk university affiliated hospital, Clinic of Obstetrics and Gynecology|
|Brno, Moravia, Czech Republic, 625 00|
|Principal Investigator:||Julie Bienertova-Vasku, MD.,, Ph.D.||Department of Pathological Physiology, Faculty of Medicine, Masaryk University|
|Study Director:||Anna Vasku, prof. Ph.D.||Department of Pathological Physiology, Faculty of Medicine, Masaryk University|
|Study Director:||Petr Bienert, Dr.||Department of Pathological Physiology, Faculty of Medicine, Masaryk University|